Description
Description: EFNB3 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 208 amino acids (28-226a.a.) andhaving a molecular mass of 23.0kDa. (Molecular size on SDS-PAGE will appear atapproximately 28-40kDa).
EFNB3 is expressed with a 6amino acid His tag at C-Terminus and purified by proprietary chromatographictechniques.
Introduction: Ephrin-B3 (EFNB3) which belongs to the ephrin gene family is essential in brain development as well as in its maintenance. EFNB3 binds to, and induces the collapse of, commissural axons/growth cones in vitro. EFNB3 loosely binds Eph receptors located on bordering cells, leading to contact-dependent bidirectional signaling into neighboring cells. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and are implicated in mediating developmental events, mostly in the nervous system