Description
Nerve Growth Factor (NGF-beta) is a neurotrophic factor related to BDNF, NT-3 and NT-4 and is involved in the development and maintenance of the sensory and sympathetic nervous systems. β-NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. β-NGF is also involved in the growth, differentiation, and survival of B lymphocytes. Human, mouse, and rat β-NGF proteins are cross-reactive