Description
Description: CNDP1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 489 amino acids (27-507 a.a.) and having a molecular mass of 54.9kDa (Migrates at 50-70kDa on SDS-PAGE under reducing conditions). CNDP1 is expressed with a 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Introduction: CNDP Dipeptidase 1, also known as CNDP1 is a member of the peptidaseM20A family. CNDP1 Mannheim which is the shortest allelic form has been morecommon in the absence of nephropathy in addition to being associated with lower serum carnosinase levels. Furthermore, Carnosine inhibited the increasedproduction of fibronectin as well as collagen type VI in podocytes and theincreased production of TGF-beta in mesangial cells. Diabetic patients with theCNDP1 Mannheim variant are less at risk for nephropathy. In addition, on renalcells carnosine protects against the adverse effects of high glucose levels