Fig 1: Levels of collagen-associated antibodies in patients with collagenous colitis and controls. Col III = collagen type III, Col IV = collagen type IV, MMP-9 = matrix metalloproteinase-9, TIMP-1 = tissue inhibitors of metalloproteinases-1, TNC = tenascin-C. CC = collagenous colitis (n = 66); treated = current budesonide treatment, controls = healthy blood donors (n = a 70, b 51, c 100, d 65, e 100). Black bars state median values. Y axis: Antibody levels in relative units (RU) (absorbance values after subtracted background). Cut-off value set at the 97.5 th percentile. Fischer's exact test was used to calculate the differences between controls and CC pat (including both treated and untreated)
Fig 2: a Presence of collagen-associated autoantibodies. Col III = collagen type III, Col IV = collagen type IV, MMP-9 = matrix metalloproteinase-9, TIMP-1 = tissue inhibitors of metalloproteinases-1, TNC = tenascin-C, CC = collagenous colitis. Relative units > 97.5 percentile in a cohort of healthy blood donors were considered as presence of antibodies. Controls consisted of α = 70, β = 51, γ = 100, δ = 65 healthy blood donors. Fischer's exact test was used to calculate the differences between groups. None of the differences between groups were statistically significant (P < 0.05). b Presence of antibodies against saccharomyces cerevisiae (ASCA), thyroid peroxidase (TPO) and increased total serum IgE. CC = Collagenous colitis. Controls consisted of α = 50 healthy blood donors, β = 254 healthy blood donors, γ = 100 healthy blood donors. Fischer's exact test was used to calculate the differences between groups. None of the differences between groups were statistically significant (P < 0.05)
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