Description
Description: EPHB2 Human Recombinant produced in Sf9 Baculovirus cellsis a single, glycosylated polypeptide chain containing 533 amino acids (19-543a.a)and having a molecular mass of 59.1kDa (Molecular size on SDS-PAGE will appearat approximately 50-70kDa). EPHB2 is fused to a 8 amino acid His-tag at C-terminus& purified by proprietary chromatographic techniques.
Introduction: EPHReceptor B2 (EPHB2) is a part of the transmembrane Eph receptor tyrosine kinasefamily (RTKs) which binds proteins of the Ephrin family on adjacent cells. Theinteraction leads to contact-dependent bidirectional signaling into neighboringcells. Hippocampal neurons can release vesicles containing full lengthEPHB2, and these are taken up by neighboring glial cells. EPHB2 takes part inthe guidance of commissural axons through the embryonic midline and regulatesdendritic spines development and maturation and stimulates the formation ofexcitatory synapses