Description
Product Characteristics: Recombinant Human Grancalcin/GCA GST-tagged produced by E. coli expression system. Target protein is expressed with sequence (Met1-Ile217) of Human (Uniprot #P28676).
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Target Information: This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction\, with magnesium alone, it partitions with the granule fraction\, and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq, Jul 2008]