Description
Phosphoramidon is a neutral endopeptidase 24.11 (NEP, neprilysin; EC 3.4.24.11) (Ki=2nM) inhibitor, which cleaves bioactive peptides such as bradykinin, neurotensin, and enkephalin. It also inhibits neprilysin 2 (Ki~2nM) and endothelin-converting enzyme (ECE) (IC50=0.68 µM)