Mouse IFNG / Interferon Gamma Protein 50709-MNAH from Sino Biological, Inc.

Product Specs
ItemMouse IFNG / Interferon Gamma Protein
CompanySino Biological, Inc.
Price $58.00Supplier Page View Company Product Page
Catalog Number50709-MNAH
Size20 µg
Conjugate/TagUnconjugated
Purity> 85 % as determined by SDS-PAGE
Activity1. Measured by its binding ability in a functional ELISA. Immobilized Mouse Interferon Gamma (Cat:50709-MNAH) at 2 µg/ml (100 µl/well) can bind Mouse IFNGR1 hFc (Cat:50705-M02H), the EC50 of Mouse IFNGR1 hFc is7.0-30.0 ng/mL. 2. Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV).The ED50 for this effect is 0.05-0.3 ng/mL
FormatLyophilized from sterile PBS, pH 7.4
TypeRecombinant protein
Molecular WeightThe recombinant mouse IFNG consists of 133 amino acids and predicts a molecular mass of 15.5 kDa. As a result of different glycosylation, it migrates as approximately 19.6 and 15.4 kDa band in SDS-PAGE under reducing conditions
SpeciesMouse
Molecule NameIFNG
Source/Expression SystemHEK293 Cells

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Immunogenic tumor cell death and T-cell-derived IFN-γ elicit tumoricidal macrophages to potentiate OX40 immunotherapyCell Reports MedicineApril 21, 2026Yanqin Liu, Jiliang Zhao, Kailu Yang, Qiongqiong Ma, Dongping Zhang, Lili Xu, Zhaoyuan Zhang, Zhongqian Yin, Jingru Chen, Yi Wang, et al.administered intraperitoneally (i.p.) at a dosage of 2.5 mg/kg. Meanwhile MPLA (vac-mpls, InvivoGen) and IFNγ (50709-MNAH, Sino Biological) were administered intratumorally (i.t.) at a dosage of 1 μg/mice and 5 μg/mice, respectively.

(2) Context‐Dependent Role of GDF15: GDF15 + Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing PhagocytosisAdvanced ScienceMarch 13, 2026Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Huand cultured for 24 h. The BMDMs were then stimulated for 24 h with 20 ng/mL of interferon‐γ (IFN‐γ, 50709‐MNAH, SinoBiological, China) and 100 ng/mL of lipopolysaccharide (LPS, L2880, Sigma–Aldrich, USA) for M1

(3) HAPI Cells are SIM-A9-related Mouse Microglial Cells Useful for In Vitro Modeling of Microglial ImmunometabolismbioRxivFebruary 16, 2026Ryan P. Mayers, Sausan M. Jaber, Nicolas Verhoeven, Ayodele Jaiyesimi, Brian M. Polstercatalogue # (Cat#) 11200). Mouse-origin recombinant IFN-γ protein was from Sino Biological (Paoli, PA; Cat# 50709-MNAH). Rat-origin recombinant IFN-γ protein was from Thermo Fisher Scientific (Waltham, MA; Cat# 400–20).

(4) PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer ImmunotherapyAdvanced ScienceFebruary 11, 2026Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, et al.replaced with fresh complete medium containing recombinant mouse IFN‐ γ (10 µg/mL, Sino Biological, 50709‐MNAH) for 4T1 cells or recombinant human IFN‐ γ (10 µg/mL, Sino Biological, 11725‐HNAS) for MDA‐MB‐231 cells.

(5) Programmed death-ligand 1 (PD-L1) Modulates Chemokine Production Via the TLR4/TRAF6 Signaling Axis During LPS + IFN-γ-Induced Endotoxemia-mimicked SepsisInflammationJanuary 10, 2026Mu Yuan, Tong Jin, Luoquan Ao, Junyu Zhu, Weijun Wan, Quan Chen, Yuchuan Yuan, Qing Zhao, Xiang Xu, Lixing Tian(Cat# 11725-HNAE) was obtained from Sinobiological (Beijing, China). Recombinant mouse IFN-γ (Cat# 50709-MNAH) was obtained from Sinobiological (Beijing, China). Trypsin, fetal bovine serum (FBS), Roswell Park

(6) PD-L1 mediates M1 polarization of macrophages via the AIM2/IL-18/STAT1 signaling axis during sepsisCell Communication and SignalingDecember 8, 2025Guomei Yang, Luoquan Ao, Qing Zhao, Chengyi Hu, Xiaofeng Wu, Mengwei Yao, Mu Yuan, Tong Jin, Weijun Wan, Quan Chen, et al.(Cat# 11725-HNAE) was obtained from Sinobiological (Beijing, China). Recombinant mouse IFN-γ (Cat# 50709-MNAH) was obtained from Sinobiological (Beijing, China). Trypsin, fetal bovine serum (FBS), RPMI-1640 medium

(7) EF1α, rather than CMV promoter, is suitable for luciferase tag expression in target cells for in vitro cytotoxicity assays of CAR-T cellsMolecular Therapy Methods & Clinical DevelopmentSeptember 11, 2025Rui Hou, Zejun Zhang, Huan Li, Wenyin He, Xu Wang, Xuan Zhao, Sijin Li, Zhangchun Guan, Dan Liu, Junnian Zheng, et al.(Sino Biological, Inc., no. 11725-H08H, for Nalm6Luc and HGC-27Luc cells) or mouse IFN-γ (Sino Biological, Inc., no. 50709-MNAH, for B16F10-Her2Luc cells) for 24 h. After that, 100 μL of firefly luciferase assay reagent was added

(8) CXCL10highTNFαhighKi67 + Microglia Recruit and Activate CD8 + T Cells in the Brainstem During Experimental Cerebral MalariaCNS Neurosci TherJune 2, 2025Yi Wang, Jiao Liang, Chao Yang, Jun Wang, Qinghao Zhu, Guodong Tong, Tong Li, Ganze Li, Yuxiao Huang, Yimin Yang, et al.(163605), and APC‐labeled CD69 (104513) for flow cytometry (FC) were purchased from BioLegend (USA). IFNγ (50709‐MNAH) was purchased from SinoBiological (China) and TNFα (05–168) was from Sigma‐Aldrich (USA). 2.4 Transmission Electron Microscopy

(9) Riboflavin kinase binds and activates inducible nitric oxide synthase to reprogram macrophage polarizationRedox biologyDecember 1, 2024Shan X, Ji Z, Wang B, Zhang Y, Dong H, Jing W, Zhou Y, Hu P, Cui Y, Li Z, et al.CO2 for 7 days. For the macrophage polarization assay, macrophages were treated with 100 ng/ml IFN-γ (50709-MNAH, Sino Biological), 100 ng/mL IFN-γ + 100 ng/mL LPS (L4516, Sigma), 100 ng/mL IFN-γ + 100 ng/mL TNF-α

(10) Prior Fc receptor activation primes macrophages for increased sensitivity to IgG via long-term and short-term mechanismsDevelopmental cellNovember 4, 2024Bond A, Fiaz S, Rollins K, Nario JEQ, Snyder ET, Atkins DJ, Rosen SJ, Granados A, Dey SS, Wilson MZ, et al.For M1 polarized cells, 100 ng/ml LPS (Sigma, Cat# L4516) and 50ng/ml IFN-ɣ (Sino Biological, Cat# 50709-MNAH) were added to the cells for 24 hours. For M2 polarized cells, 20 ng/ml IL-4 (Sino Biological, Cat#

(11) Adenosine A2A receptor activation regulates the M1 macrophages activation to initiate innate and adaptive immunity in psoriasisClinical immunology (Orlando, Fla.)September 1, 2024Lu Y, Zhu W, Zhang GX, Chen JC, Wang QL, Mao MY, Deng SC, Jin LP, Liu H, Kuang YH.

(12) Tregs delivered post-myocardial infarction adopt an injury-specific phenotype promoting cardiac repair via macrophages in miceNature communicationsAugust 1, 2024Alshoubaki YK, Nayer B, Lu YZ, Salimova E, Lau SN, Tan JL, Amann-Zalcenstein D, Hickey PF, Del Monte-Nieto G, Vasanthakumar A, et al.

(13) Glycoprotein Non-metastatic Melanoma Protein B (GPNMB) Protects Against Neuroinflammation and Neuronal Loss in Pilocarpine-induced Epilepsy via the Regulation of Microglial PolarizationNeuroscienceJuly 23, 2024Hou X, Xiao S, Xu X, Qin M, Cheng X, Xu X.

(14) M1 macrophage-derived exosomes inhibit cardiomyocyte proliferation through delivering miR-155BMC cardiovascular disordersJuly 16, 2024He X, Liu S, Zhang Z, Liu Q, Dong J, Lin Z, Chen J, Li L, Liu W, Liu S, et al.

(15) Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by CD8(+) T cells in cerebral malariaJournal of neuroinflammationMay 7, 2024Wang Y, Shen Y, Liang J, Wang S, Huang Y, Zhu Q, Zhang X, Yu K, Tong G, Yang C, et al.and FITC-labeled H-2 Kb/H-2Db (114605) for flow cytometry were purchased from BioLegend (USA). IFNγ (50709-MNAH) was purchased from SinoBiological (China) and IFNβ (I9032-1VL) was from Sigma-Aldrich (USA). Fludarabine

(16) A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune responseNature communicationsApril 2, 2024Yang H, Wu X, Li X, Zang W, Zhou Z, Zhou Y, Cui W, Kou Y, Wang L, Hu A, et al.intervention group (CDI+rIFN-γ group) was intraperitoneally injected with 10 μg rIFN-γ recombinant protein (50709-MNAH, SinoBiological, China) at 2 h and 24 h after C. difficile infection. To study the role of several amino

(17) Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosisZoological ResearchMarch 18, 2024Poornima D.E. Weerasinghe-Mudiyanselage, Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea, Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea, Sohi Kang, Joong-Sun Kim, Sung-Ho Kim, Hongbing Wang, Taekyun Shin, Changjong Moon, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Republic of Korea, et al.R&D Systems, USA), tumor necrosis factor alpha (TNFα; #315-01A, PeproTech, USA), and interferon gamma (IFNγ; #50709-MNAH, Sino Biological, China)), respectively. The cytokine treatment protocol followed previous studies (Kim

(18) Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinomaNature communicationsFebruary 2, 2024Liu C, Zhou C, Xia W, Zhou Y, Qiu Y, Weng J, Zhou Q, Chen W, Wang YN, Lee HH, et al.no. 570202) was obtained from BioLegend. Mouse IL-4 (cat. no. 51084-MNAE) and mouse IFN-γ (cat. no. 50709-MNAH) were obtained from Sino Biological. The ALKi crizotinib (cat. no. PF-02341066) was purchased from Selleck

(19) E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLCCell reportsDecember 26, 2023Tang F, Lu C, He X, Lin W, Xie B, Gao X, Peng Y, Yang D, Sun L, Weng L.

(20) Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitisiScienceNovember 17, 2023Yoshiyuki Akiyama, Kaori Harada, Jimpei Miyakawa, Karl J. Kreder, Michael A. O’Donnell, Maeda Daichi, Hiroto Katoh, Miyuki Hori, Kensuke Owari, Kazunobu Futami, et al.(D-PBS) was obtained from Nacalai Tesque (Kyoto, Japan). Recombinant mouse IFN-γ proteins (#50709-M02H, #50709-MNAH) were purchased from Sino Biological (Beijing, China). An Alexa Fluor 488-conjugated mouse anti-STAT1

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Mouse IFNG / Interferon Gamma Protein

Mouse IFNG / Interferon Gamma Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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Mouse IFNG / Interferon Gamma Protein from Sino Biological, Inc.

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