Mouse / Rat TGF-beta 1 / TGFB1 Protein 80116-RNAH from Sino Biological, Inc.

Product Specs
ItemMouse / Rat TGF-beta 1 / TGFB1 Protein
CompanySino Biological, Inc.
Price $68.00Supplier Page View Company Product Page
Catalog Number80116-RNAH
Size5 µg
Conjugate/TagUnconjugated
Purity> 90 % as determined by SDS-PAGE
Activity1.Measured by its ability to inhibit cell proliferation of Mv-1-lu mink lung epithelial cells. The ED50 for this effect is typically 0.02-0.2 ng/mL. 2.The expression of IL11 and Acta2 mRNA in mouse fibroblasts was up-regulated after being cultured with 100ng/mL TGFB1 (Cat#80116-RNAH) for 24 hours. Data provided by Dr. Song at China Agricultural University
FormatLyophilized from sterile PBS, pH 3.0
TypeRecombinant protein
Molecular WeightThe recombinant mouse / rat TGFB1 comprises 112 amino acids and predicts a molecular mass of 12.8 kDa
SpeciesMouse, Rat
Molecule NameTGFB1
Source/Expression SystemHEK293 Cells

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Colonic Engyodontium fungus triggers neutrophil antimicrobial activity to suppress Lactobacillus johnsonii-derived glutamic acid-maintained TregsJournal of Clinical InvestigationApril 15, 2026Xinying Wang, Haiyang Sun, Ying Tan, Shaoting Xu, Zishan Liu, Kaile Ji, Ding Qiu, Jianping Deng, Bingbing Feng, Xueting Wu, et al.beads/well; 11456D, Thermo Fisher Scientific). Treg differentiation was induced with TGF-β (5 ng/mL; 80116-RNAH, Sino Biological) and IL-2 (212-12, PeproTech) for 6 days. Th1 differentiation used IL-12 (5 ng/mL;

(2) Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1Redox BiologyMarch 1, 2026Yan Chen, Zhewei Zhang, Yue Cheng, Xiaofeng Chen, Junteng Zhou, Zisong Wei, Han Yao, Shuwen Zhang, Qihang Kong, Hao Tang, et al.serum-free DMEM for 4 h. Subsequently, they were treated with 10 ng/mL TGF-β1 (Sino Biological Inc. 80116-RNAH, China) for 24 h to induce activation. For siRNA transfection, CFs were transfected either with siRNA-circSamd4

(3) Notch Signaling Exacerbates Pulmonary Fibrosis by Regulating the Differentiation of CD4+ Tissue-Resident Memory T CellsBiomoleculesFebruary 20, 2026Jia Shi, Ruiting Su, Lili Zhuang, Zhangmei Lin, Xinyuan Ruan, Yichao Qian, Jieying Zhu, Shuyi Wang, Niansheng Yangculturing activated cells in complete medium with 10 ng/mL TGF-β (Sino Biological, Beijing, China, Cat# 80116-RNAH-5) over a 3-day period, following previously reported methods [25]. As previously described, primary

(4) Neutrophil extracellular traps exacerbate inflammatory arthritis by inhibiting γδ Treg cell differentiation via the AIM2 inflammasomeRedox BiolSeptember 30, 2025Yipeng Zeng, Jiajie Lin, Zipeng Xiao, Zhikun Li, Guan Zheng, Yi Zhou, Qibo Li, Chenying Zeng, Zepeng Su, Wenhui Yu, et al.Biolegend, #117003), IL-2 (10 ng/mL; Yeasen Biotechnology; #90142 ES) and TGF-β (2 ng/mL; Sino Biological; #80116-RNAH) were added. Mouse ankle joints were collected, mechanically dissociated and treated with 5 mg/mL collagenase

(5) Overexpression miR-125a-5p inhibits HSCs activation and alleviates liver fibrosis through TGF-β/Smad2/3 signaling pathway and autophagyCell Death DiscoverySeptember 1, 2025Chunyan Zhang, Yabin Zhao, Haoyu Yan, Jianlin Guo, GuoYing Yutreatment HSC-T6 cells (CL-0116, Procell) were classified as four groups following as control group, TGF-β (80116-RNAH, SinoBiological) treatment group (48 h of 5 ng/ml TGF-β treatment), TGF-β+mimic NC group (24 h of 5

(6) Chimeric antigen receptor-engineered cytolytic Tregs reverse pulmonary fibrosis and remodel the fibrotic niche without CRSJCI InsightAugust 8, 2025Yun-Han Jiang, Meng Zhou, Meng-Di Cheng, Sai Chen, Ying-Qiang Guo(MedChemExpress, HY-126675), 1 nM retinoic acid (MedChemExpress, HY-14649), and 2 ng/mL TGF-β1 (Sino Biological, 80116-RNAH) for 5 days. CD8+CD25+ Tregs were purified from stimulated T cells via magnetic cell sorting (Miltenyi

(7) ACSL4 Drives C5a/C5aR1–Calcium-Induced Fibroblast-to-Myofibroblast Transition in a Bleomycin-Induced Mouse Model of Pulmonary FibrosisBiomoleculesJuly 31, 2025Tingting Ren, Jia Shi, Lili Zhuang, Ruiting Su, Yimei Lai, Niansheng Yangsubsequent functional experiments. In some experiments, TGF-β1 (Sinobiological, Beijing, China, Cat#: 80116-RNAH-5), PRGL493, C5a (MCE, New Jersey, USA, Cat#: HY-P7695), or FK506 (Selleck, Texas, USA, Cat#: S5003)

(8) TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositisNat CommunMay 15, 2025Yimei Lai, Shuang Wang, Tingting Ren, Jia Shi, Yichao Qian, Shuyi Wang, Mianjing Zhou, Ryu Watanabe, Mengyuan Li, Xinyuan Ruan, et al.Th17 cells: anti-IFNγ antibody (5 μg/ml), anti-IL-4 antibody (5 μg/ml), TGFβ1 (2 ng/ml, Sino Biological, Cat# 80116-RNAH-5), IL-6 (40 ng/ml, Sino Biological, Cat# 50136-MNAE), IL-23 (30 ng/ml, NovoProtein, Cat# C03U), and

(9) Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion InjuryAdvanced ScienceMarch 16, 2025Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, et al.treated with either PBS or transforming growth factor‐β1 (TGF‐β1) at a concentration of 10 ng mL−1 (80116‐RNAH‐5, Sino Biological, China) to induce fibrosis under baseline and TGF‐β1‐stimulated conditions, respectively.

(10) Macrophage erythropoietin signaling promotes macrophage-myofibroblast transformation and fibroblast-myofibroblast differentiationBiochemical and biophysical research communicationsNovember 19, 2024Wu P, Zhang W, Guan H, Jin T, Jia J, Luo B, Wang G, Zhang Z.

(11) Quantitative proteomics reveals the mechanism of endoplasmic reticulum stress-mediated pulmonary fibrosis in miceHeliyonOctober 30, 2024Heng Li, Jin Wang, Ziling Li, Zhidong Wu, Yan Zhang, Lingjia Kong, Qingqing Yang, Dong Wang, He Shi, Guozheng Shen, et al.signaling pathways. 2 Materials and methods 2.1 Chemicals and reagents Recombinant mouse TGF-β protein (80116-RNAH) was obtained from Sino Biological (Beijing, China). Fetal bovine serum was from TIANHANG biotechnology

(12) MICALL2 participates in the regulation of epithelial-mesenchymal transition in alveolar epithelial cells - Potential roles in pulmonary fibrosisArchives of biochemistry and biophysicsOctober 1, 2023Chen Y, Song W, Zhang H, Ji X.

(13) CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD signaling in osteogenesis imperfectaMatrix biology : journal of the International Society for Matrix BiologyJune 1, 2023Besio R, Contento BM, Garibaldi N, Filibian M, Sonntag S, Shmerling D, Tonelli F, Biggiogera M, Brini M, Salmaso A, et al.harvested after 5 days. For TGF-β treatment, cells were treated with 50 ng/mL TGF-β (Sino Biological, 80116-RNAH) for 1h. For CaMKII inhibition, cells were incubated with 1 μM KN-93 (Sigma Aldrich) for 1h. For mineralization

(14) Honokiol Suppresses Perineural Invasion of Pancreatic Cancer by Inhibiting SMAD2/3 SignalingFrontiers in oncologyJanuary 1, 2021Qin T, Li J, Xiao Y, Wang X, Gong M, Wang Q, Zhu Z, Zhang S, Zhang W, Cao F, et al.secondary antibodies (Proteintech). Recombinant human TGF-β1 (10804-HNAC) and recombinant mouse TGF-β1 (80116-RNAH) were purchased from Sino Biological (Beijing, China). HNK was purchased from MedChem Express (Monmouth

(15) CircPlekha7 plays an anti-fibrotic role in intrauterine adhesions by modulating endometrial stromal cell proliferation and apoptosisThe Journal of reproduction and developmentDecember 22, 2020Xie W, He M, Liu Y, Huang X, Song D, Xiao Y.density of 2 × 105 cells/well for 24 h, followed by 109 incubation with TGF-β1 (10 ng/ml, Cat. No. 80116-RNAH, Sino Biological US Inc., Wayne, 110 PA, USA) for 24 h to induce fibrosis (IUA model cell). These

(16) CTGF Triggers Rat Astrocyte Activation and Astrocyte-Mediated Inflammatory Response in Culture ConditionsInflammationOctober 1, 2019Lu M, Yan XF, Si Y, Chen XZ.

(17) Inhibition of TGF-β induced lipid droplets switches M2 macrophages to M1 phenotypeToxicology in vitro : an international journal published in association with BIBRAAugust 1, 2019Bose D, Banerjee S, Chatterjee N, Das S, Saha M, Saha KD.

(18) A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaquesScientific reportsJuly 16, 2018Cockrell AS, Johnson JC, Moore IN, Liu DX, Bock KW, Douglas MG, Graham RL, Solomon J, Torzewski L, Bartos C, et al.

(19) Deficient O-GlcNAc Glycosylation Impairs Regulatory T Cell Differentiation and Notch Signaling in Autoimmune HepatitisFrontiers in immunologyJanuary 1, 2018Hao X, Li Y, Wang J, Ma J, Zhao S, Ye X, He L, Yang J, Gao M, Xiao F, et al.

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Mouse / Rat TGF-beta 1 / TGFB1 Protein

Mouse / Rat TGF-beta 1 / TGFB1 Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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Mouse / Rat TGF-beta 1 / TGFB1 Protein from Sino Biological, Inc.

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