Description
Introduction: Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7, also known as CHCHD7 is a newly recognized member of a multifamily of proteins which contains a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain. The biological function of CHCHD7 is unknown and the gene has up till now not been connected with neoplasia. In addition, CHCHD7 & PLAG1 are located head-to-head about 500 bp apart in 8q12. Molecular analyses of twenty seven tumors exposed CHCHD7-PLAG1 fusions in three tumors, two of them had t(6;8) and t(8;15) translocations as a singular anomalies and one a normal karyotype.
Description: CHCHD7 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (1-97 a.a) and having a molecular mass of 13.9kDa. CHCHD7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques