Description
Introduction: SCO Cytochrome Oxidase Deficient Homolog 1, also known as SCO1 is a member of the SCO1/2 family. Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Furthermore, in yeast, two related COX assembly genes, SCO1 & SCO2 which are synthesis of cytochrome c oxidase, enable subunits 1 as well as 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. Among the diseases associated with SCO1 are hepatic failure, early-onset, neurologic disorder due to cytochrome c oxidase deficiency and fatal infantile cytochrome c oxidase deficiency.
Description: SCO1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (132-301 a.a) and having a molecular mass of 20.5kDa. SCO1 is fused to a 9 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques