Description
The IgE receptor subunit A(also known as Fce RIA or FceRIA) is a subunit of IgE receptor, present as a transmembrane glycoprotein. IgE receptor is a tetrameric complex consisting of one A, one B and two G subunits on mast cells and basophils. The subunit A is responsible for the binding to IgE, while the G subunit is essential for cell signaling and the B subunit increase the half life of the Fce RI on the cell surface. IgE receptor subunit A is important in some disease, the patients with chronic urticaria has high concentration of circulating autoantibodies that crosslink Fce RIA with IgE. The 201 amino acids full length of human IgE receptor subunit A was expressed in E Coli with a 6 x his tag as its C-terminal