Recombinant Human GFR alpha-1 Fc Chimera Protein, CF 714-GR-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human GFR alpha-1 Fc Chimera Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $454.00Supplier Page View Company Product Page
Catalog Number714-GR-100
SpeciesHuman
Molecule NameGFR alpha-1/GDNF R alpha-1
Size100 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS
NCBI Full Gene NameGDNF family receptor alpha 1
NCBI Gene AliasesRHDA4, GDNFR-alpha-1, GDNFRA, GFR-ALPHA-1, RET1L, TRNR1, GFRalpha-1, GDNFR, RETL1
Purity>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 88-95 kDa, reducing conditions
Theoretical: 73.3 kDa (monomer)
ApplicationsBinding Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human GFR alpha-1 Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signalingbioRxivApril 2, 2026Louis S. Prahl, Ronald Canlla, Aria Zheyuan Huang, Daniel S. Alber, Sandra L. Shefter, Sachin N. Davis, Samuel H. Grindel, Zikang Dennis Huang, Thomas R. Mumford, William Benman, et al.were treated with 50 ng ml−1 GDNF (#212-GD-050, R&D Systems) and 100 ng ml−1 recombinant human Gfrα1 (#714-GR-100, R&D Systems) at defined time points. Cells were kept in a humidified incubator at 37°C and 5%CO2 for

(2) Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neuronsCell death & diseaseJuly 7, 2022Rhymes ER, Tosolini AP, Fellows AD, Mahy W, McDonald NQ, Schiavo G.

(3) Optogenetic delivery of trophic signals in a genetic model of Parkinson's diseasePLoS geneticsApril 1, 2021Ingles-Prieto A, Furthmann N, Crossman SH, Tichy AM, Hoyer N, Petersen M, Zheden V, Biebl J, Reichhart E, Gyoergy A, et al.

(4) FAT4 Fine-Tunes Kidney Development by Regulating RET SignalingDevelopmental cellMarch 25, 2019Zhang H, Bagherie-Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, Kuure S, Jain S, McNeill H.recombinant hGDNF (150ng/ml, R&D system, 212-GD-010) and hGFRA1-Fc Chimera Protein (500ng/ml, R&D system, 714-GR-100) for 10min or 30min as indicated, and then lysed in lysis buffer containing 25mM Tris, pH7.4, 1% NP40,

(5) RET Signaling in Prostate CancerClinical cancer research : an official journal of the American Association for Cancer ResearchAugust 15, 2017Ban K, Feng S, Shao L, Ittmann M.

(6) DDX4-EGFP transgenic rat model for the study of germline development and spermatogenesisBiology of reproductionMarch 1, 2017Gassei K, Sheng Y, Fayomi A, Mital P, Sukhwani M, Lin CC, Peters KA, Althouse A, Valli H, Orwig KE.

(7) Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degenerationThe Journal of clinical investigationMay 1, 2015Meka DP, Müller-Rischart AK, Nidadavolu P, Mohammadi B, Motori E, Ponna SK, Aboutalebi H, Bassal M, Annamneedi A, Finckh B, et al.

(8) Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutantsThe EMBO journalFebruary 18, 2014Klein P, Müller-Rischart AK, Motori E, Schönbauer C, Schnorrer F, Winklhofer KF, Klein R.

(9) Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2APloS oneJanuary 1, 2014Kales SC, Nau MM, Merchant AS, Lipkowitz S.cycloheximide (#C7698) was purchased from Sigma Aldrich (St. Louis, MO). Recombinant human RET ligand (GDNF; #714-GR-100) and exogenous co-receptor (GFRα1; #212-GD-010/CF) were purchased from R&D Systems (Minneapolis, MN). Expression

(10) Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signalingThe Journal of neuroscience : the official journal of the Society for NeuroscienceMarch 20, 2013Gatto G, Dudanova I, Suetterlin P, Davies AM, Drescher U, Bixby JL, Klein R.

(11) RET PLCγ phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migrationPloS oneJanuary 1, 2012Lundgren TK, Nakahata K, Fritz N, Rebellato P, Zhang S, Uhlén P.

(12) A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruziInfection and immunityAugust 1, 2008Lu B, PereiraPerrin M.

(13) Neurturin-GFRalpha2 signaling controls liver bud migration along the ductus venosus in the chick embryoDevelopmental biologyJuly 1, 2007Tatsumi N, Miki R, Katsu K, Yokouchi Y.

(14) A specific survival response in dopamine neurons at most risk in Parkinson's diseaseThe Journal of neuroscience : the official journal of the Society for NeuroscienceSeptember 20, 2006Murase S, McKay RD.

(15) Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus arteminBiochemistryFebruary 22, 2005Carmillo P, Dagø L, Day ES, Worley DS, Rossomando A, Walus L, Orozco O, Buckley C, Miller S, Tse A, et al.

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Recombinant Human GFR alpha-1 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human GFR alpha-1 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

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