Recombinant Human/Cynomolgus/Rhesus Macaque CD28 Fc, CF 342-CD-200 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human/Cynomolgus/Rhesus Macaque CD28 Fc, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $516.00Supplier Page View Company Product Page
Catalog Number342-CD-200
SpeciesHuman, Cynomolgus Monkey, Rhesus Macaque
Size200 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS
Molecule NameCD28
NCBI Full Gene NameCD28 molecule
NCBI Gene AliasesTp44
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 60-70 kDa, reducing conditions
Theoretical: 42.2 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human/Cynomolgus/Rhesus Macaque CD28 Fc, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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(2) Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumabProceedings of the National Academy of Sciences of the United States of AmericaMay 23, 2017Ramagopal UA, Liu W, Garrett-Thomson SC, Bonanno JB, Yan Q, Srinivasan M, Wong SC, Bell A, Mankikar S, Rangan VS, et al.

(3) Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitisJournal of immunology (Baltimore, Md. : 1950)February 15, 2015Haanstra KG, Dijkman K, Bashir N, Bauer J, Mary C, Poirier N, Baker P, Crossan CL, Scobie L, 't Hart BA, et al.were quantified by ELISA. In brief, 96-well microtiter plates were coated with CD28Fc (catalog no. 342-CD-200; R&D Systems) at 2 mg/ml in carbonate buffer (pH 9) at 50 ml/well overnight at 4˚C. After washing, free

(6) Autoantibodies against CD28 are associated with atopic diseasesClinical and experimental immunologyNovember 1, 2006Neuber K, Mähnss B, Hübner C, Gergely H, Weichenthal M.

(7) Chimeric co-stimulatory molecules that selectively act through CD28 or CTLA-4 on human T cellsThe Journal of biological chemistryOctober 11, 2002Lazetic S, Leong SR, Chang JC, Ong R, Dawes G, Punnonen J.

Recombinant Human/Cynomolgus/Rhesus Macaque CD28 Fc, CF from R&D Systems, a Bio-Techne Brand