Recombinant Human HGF (NS0-expressed) Protein 294-HGN-005 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human HGF (NS0-expressed) Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $272.00Supplier Page View Company Product Page
Catalog Number294-HGN-005
SpeciesHuman
Size5 ug (also 25 ug, 100 ug, 250 ug, 1 mg)
Molecule NameHGF
NCBI Full Gene Namehepatocyte growth factor
NCBI Gene AliasesDFNB39, HPTA, F-TCF, SF, HGFB
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 71-85 kDa, non-reducing conditions 56-65 kDa and 30-40 kDa, reducing conditions
Theoretical: alpha chain: 53.7 kDaÃŸ chain: 26 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human HGF (NS0-expressed) Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Betaglycan sustains HGF/Met signaling in lung cancer and endothelial cells promoting cell migration and tumor growthHeliyonMay 15, 2024Cervantes-Villagrana RD, Mendoza V, Hinck CS, de la Fuente-León RL, Hinck AP, Reyes-Cruz G, Vázquez-Prado J, López-Casillas F.

(2) MET Oncogene Enhances Pro-Migratory Functions by Counteracting NMDAR2B CleavageCellsDecember 21, 2023Gallo S, Vitacolonna A, Comoglio PM, Crepaldi T.

(3) MET Oncogene Controls Invasive Growth by Coupling with NMDA ReceptorCancersSeptember 11, 2022Gallo S, Vitacolonna A, Comoglio P, Crepaldi T.

(4) A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signalingNature communicationsJune 21, 2022Erdem C, Mutsuddy A, Bensman EM, Dodd WB, Saint-Antoine MM, Bouhaddou M, Blake RC, Gross SM, Heiser LM, Feltus FA, et al.treated with vehicle control, EGF (10 ng/mL, PeproTech #AF-100-15), and HGF (40 ng/mL, R&D Systems #294-HGN-005) for 0, 5, and 60 min in a humidified, 5% CO2, 37 °C incubator. Collagen-coated plates and growth-factor

(5) Detection and quantification of human-specific mRNA from hepatocyte-like cells derived from dental pulp using real-time polymerase chain reactionJournal of oral biosciencesSeptember 1, 2021Shimamura N, Fujii K, Ohkoshi S.

(6) cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunitsThe Journal of biological chemistryFebruary 15, 2019Adame-García SR, Cervantes-Villagrana RD, Orduña-Castillo LB, Del Rio JC, Gutkind JS, Reyes-Cruz G, Taylor SS, Vázquez-Prado J.

(7) Enhancement of HGF-induced tubulogenesis by endothelial cell-derived GDNFPloS oneJanuary 1, 2019Nakasatomi M, Takahashi S, Sakairi T, Ikeuchi H, Kaneko Y, Hiromura K, Nojima Y, Maeshima A.epithelial-endothelial crosstalk during tubule formation. Materials and methods Reagents Human recombinant HGF (294-HGN-005) and GDNF (212-GD-010) were obtained from R&D Systems (Minneapolis, MN). Growth factor-reduced Matrigel

(8) Promotion of malignant phenotype after disruption of the three-dimensional structure of cultured spheroids from colorectal cancerOncotargetMarch 23, 2018Piulats JM, Kondo J, Endo H, Ono H, Hagihara T, Okuyama H, Nishizawa Y, Tomita Y, Ohue M, Okita K, et al.(Life Technologies, 13256029), EGF (Life Technologies, PHG0311L), and HGF (R&D Systems, Minneapolis, MN, 294-HGN-005). Basal medium consisted of DMEM/F12, 1x GlutaMAX, 0.1 mM 2-mercaptoethanol, and 2% BSA. Mechanical

(9) Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancerProceedings of the National Academy of Sciences of the United States of AmericaOctober 10, 2017Jahangiri A, Nguyen A, Chandra A, Sidorov MK, Yagnik G, Rick J, Han SW, Chen W, Flanigan PM, Schneidman-Duhovny D, et al.

(10) Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3Scientific reportsMarch 2, 2017He H, Kuriyan AE, Su CW, Mahabole M, Zhang Y, Zhu YT, Flynn HW, Parel JM, Tseng SC.

(11) Human Stem Cell-Derived Endothelial-Hepatic Platform for Efficacy Testing of Vascular-Protective Metabolites from NutraceuticalsStem cells translational medicineMarch 1, 2017Narmada BC, Goh YT, Li H, Sinha S, Yu H, Cheung C.seeding them in step IV differentiation medium with hepatocyte growth factor (R&D Systems, catalog no. 294‐HGN‐005), Follistatin (R&D Systems, catalog no. FS‐288), Oncostatin (R&D Systems, catalog no. 295‐OM‐010), and

(12) Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesionOncogeneApril 7, 2016Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, et al.

(13) Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplificationBMC cancerFebruary 16, 2016Wang J, Goetsch L, Tucker L, Zhang Q, Gonzalez A, Vaidya KS, Oleksijew A, Boghaert E, Song M, Sokolova I, et al.

(14) Ligand-independent activation of MET through IGF-1/IGF-1R signalingInternational Journal of CancerOctober 1, 2013Andreas Varkaris, Sanchaika Gaur, Nila U. Parikh, Jian H. Song, Farshid Dayyani, Jung-Kang Jin, Christopher J. Logothetis, Gary E. GallickDNA fingerprints. NIH-PA Author Manuscript Reagents and chemicals IGF-1 (Catalog # 291-G1) and HGF (Catalog # 294-HGN-005) were purchased from R&D Systems (Minneapolis, MN) and dissolved in PBS. Actinomycin D (Catalog # A1410)

(15) Tivantinib (ARQ197) displays cytotoxic activity that is independent of its ability to bind METClinical cancer research : an official journal of the American Association for Cancer ResearchMay 1, 2013Basilico C, Pennacchietti S, Vigna E, Chiriaco C, Arena S, Bardelli A, Valdembri D, Serini G, Michieli P.

(16) Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cellsPloS oneAugust 11, 2010Roelandt P, Pauwelyn KA, Sancho-Bru P, Subramanian K, Bose B, Ordovas L, Vanuytsel K, Geraerts M, Firpo M, De Vos R, et al.

(17) Development and validation of sandwich ELISA microarrays with minimal assay interferenceJournal of proteome researchJune 1, 2008Gonzalez RM, Seurynck-Servoss SL, Crowley SA, Brown M, Omenn GS, Hayes DF, Zangar RC.

(18) Hepatocyte growth factor and its role in the pathogenesis of retinal detachmentInvestigative ophthalmology & visual scienceJanuary 1, 2004Jin M, Chen Y, He S, Ryan SJ, Hinton DR.

(19) Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3Cancer researchFebruary 15, 2003Barbour AP, Reeder JA, Walsh MD, Fawcett J, Antalis TM, Gotley DC.

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HGF Protein

HGF Protein

Recombinant Human HGF (NS0-expressed) Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

Citations (19)

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Recombinant Human HGF (NS0-expressed) Protein from R&D Systems, a Bio-Techne Brand

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