Recombinant Human BID (Caspase-8-cleaved) Protein, CF 882-B8-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human BID (Caspase-8-cleaved) Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $491.00Supplier Page View Company Product Page
Catalog Number882-B8-050
SpeciesHuman
Size50 ug
FormatSupplied as a 0.2 µm filtered solution in HEPES-KOH and KCl
Molecule NameBID
NCBI Full Gene NameBH3 interacting domain death agonist
NCBI Gene AliasesFP497
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 9 kDa &14 kDa, reducing conditions
Theoretical: 7 kDa (N-terminal fragment) & 15 kDa (C-terminal fragment)
ApplicationsEnzyme Activity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human BID (Caspase-8-cleaved) Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) CREB1-BCL2 drives mitochondrial resilience in RAS GAP-dependent breast cancer chemoresistanceOncogeneMay 1, 2025Man KF, Darweesh O, Hong J, Thompson A, O'Connor C, Bonaldo C, Melkonyan MN, Sun M, Patel R, Ellisen LW, et al.

(2) Tethering of hexokinase 2 to mitochondria promotes resistance of liver cancer cells to natural killer cell cytotoxicityEuropean journal of immunologySeptember 1, 2024Aublin-Gex A, Jacolin F, Diaz O, Jacquemin C, Marçais A, Walzer T, Lotteau V, Vidalain PO, Perrin-Cocon L.

(3) Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistanceThe EMBO journalApril 19, 2022Çoku J, Booth DM, Skoda J, Pedrotty MC, Vogel J, Liu K, Vu A, Carpenter EL, Ye JC, Chen MA, et al.Mitochondria (50 μl of 1 μg/μl protein) were treated with caspase‐8‐cleaved tBid from 5 to 500 nM (882‐B8‐050, R&D Systems, Minneapolis, MN), Bim‐BH3 from 10 to 10,000 nM (Ac‐DMRPEIWIAQELRRIGDEFNAYYARR‐amide; New

(4) Organelle degradation in the lens by PLAAT phospholipasesNatureApril 1, 2021Morishita H, Eguchi T, Tsukamoto S, Sakamaki Y, Takahashi S, Saito C, Koyama-Honda I, Mizushima N.

(5) Eltrombopag directly inhibits BAX and prevents cell deathNature communicationsFebruary 18, 2021Spitz AZ, Zacharioudakis E, Reyna DE, Garner TP, Gavathiotis E.Recombinant tBID in >95% purity by SDS-PAGE under reducing conditions was purchased by R&D Systems (cat. # 882-B8-050). Eltrombopag (cat. # 100941) and Eltrombopag methyl ester (cat. # SC498745) were purchased from Medkoo

(6) A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathyNature CancerAugust 11, 2020Dulguun Amgalan et al.DKO MEFs were incubated with 25 nM recombinant human BAX, 10 nM recombinant human tBID (R&D Systems, 882-b8–050) with or without 10 μM BAI1 at 37 °C. After 50 min, mitochondria were centrifuged at 8,000g and cytochrome

(7) Mitochondrial Isolation and Real-Time Monitoring of MOMPMethods in Molecular BiologyFebruary 15, 2019Mark P. A. Luna-Vargas, Jarvier N. Mohammed, Jesse D. Gelles, Jerry Edward Chipuk,R&D Systems,894-BX-050 Full-length BID,1–195,-,R&D Systems,846-BD-050 Caspase-8 cleaved BID,"1–60, 61–195",-,R&D Systems,882-B8–050 BAD BH3 peptide,140–165,-,AnaSpec,AS-64082 BAK BH3,71–87,-,AnaSpec,AS-61616 "BAX BH3 peptide, wild

(8) Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human CancerCell reportsSeptember 25, 2018Guerra RM, Bird GH, Harvey EP, Dharia NV, Korshavn KJ, Prew MS, Stegmaier K, Walensky LD.BFL-1,Walensky Lab,N/A GST MCL-1ΔNΔC,Walensky Lab,N/A GST BCL-XLΔC,Walensky Lab,N/A tBID,R & D Systems,Cat# 882-B8–050 Complete Protease Inhibitor Cocktail Tablets,Sigma-Aldrich,Cat# 16829800 IPTG,Gold Biotechnology,Cat#

(9) Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranesProceedings of the National Academy of Sciences of the United States of AmericaJanuary 10, 2017Andreu-Fernández V, Sancho M, Genovés A, Lucendo E, Todt F, Lauterwasser J, Funk K, Jahreis G, Pérez-Payá E, Mingarro I, et al.

(10) The porin VDAC2 is the mitochondrial platform for Bax retrotranslocationScientific reportsSeptember 13, 2016Lauterwasser J, Todt F, Zerbes RM, Nguyen TN, Craigen W, Lazarou M, van der Laan M, Edlich F.

(11) Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpainThe Journal of biological chemistryOctober 13, 2006Shulga N, Pastorino JG.

(12) Increase in the ratio of mitochondrial Bax/Bcl-XL induces Bax activation in human leukemic K562 cell lineApoptosis : an international journal on programmed cell deathMay 1, 2004Liu FT, Goff LK, Hao JH, Newland AC, Jia L.

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Recombinant Human BID (Caspase-8-cleaved) Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human BID (Caspase-8-cleaved) Protein, CF from R&D Systems, a Bio-Techne Brand

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