Recombinant Human Angiopoietin-2 Protein, CF 623-AN-025/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Angiopoietin-2 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $381.00Supplier Page View Company Product Page
Catalog Number623-AN-025/CF
SpeciesHuman
Size25 ug (also 1 mg)
FormatLyophilized from a 0.2 µm filtered solution in MOPS, NaCl, CHAPS and PEG with Trehalose
Molecule NameAngiopoietin-2
NCBI Full Gene Nameangiopoietin 2
NCBI Gene AliasesLMPHM10, ANG2, AGPT2
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 66 kDa, reducing conditions
Theoretical: 56 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human Angiopoietin-2 Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution. 1 month, 2 to 8 °C under sterile conditions after reconstitution

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

(1) An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zoneExperimental & molecular medicineFebruary 1, 2023Lee E, Lee EA, Kong E, Chon H, Llaiqui-Condori M, Park CH, Park BY, Kang NR, Yoo JS, Lee HS, et al.

(2) TIE2-high cervical cancer cells promote tumor angiogenesis by upregulating TIE2 and VEGFR2 in endothelial cellsTranslational oncologyDecember 1, 2022Tan S, Chen Y, Du S, Li W, Liu P, Zhao J, Yang P, Cai J, Gao R, Wang Z.

(3) Gastric Cancer-Derived Extracellular Vesicles (EVs) Promote Angiogenesis via Angiopoietin-2CancersJune 15, 2022Kalfon T, Loewenstein S, Gerstenhaber F, Leibou S, Geller H, Sher O, Nizri E, Lahat G.

(4) Angpt2/Tie2 autostimulatory loop controls tumorigenesisEMBO molecular medicineMay 9, 2022Karabid NM, Wiedemann T, Gulde S, Mohr H, Segaran RC, Geppert J, Rohm M, Vitale G, Gaudenzi G, Dicitore A, et al.

(5) Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse modelNature communicationsJanuary 25, 2021Zhou HJ, Qin L, Jiang Q, Murray KN, Zhang H, Li B, Lin Q, Graham M, Liu X, Grutzendler J, et al.

(6) Angiopoietin-2 Promotes Inflammatory Activation in Monocytes of Systemic Sclerosis PatientsInternational journal of molecular sciencesDecember 15, 2020Carvalheiro T, Lopes AP, van der Kroef M, Malvar-Fernandez B, Rafael-Vidal C, Hinrichs AC, Servaas NH, Bonte-Mineur F, Kok MR, Beretta L, et al.

(8) Influence of Stress and Depression on the Immune System in Patients Evaluated in an Anti-aging UnitFrontiers in psychologyJanuary 1, 2020Cañas-González B, Fernández-Nistal A, Ramírez JM, Martínez-Fernández V.

(9) Rapid Development of Glaucoma Via ITV Nonselective ANGPT 1/2 Antibody: A Potential Role for ANGPT/TIE2 Signaling in Primate Aqueous Humor OutflowInvestigative ophthalmology & visual scienceOctober 1, 2019Thackaberry EA, Zhou Y, Zuch de Zafra CL, Fuh G, Lee CV, Sanowar S, Ridgway JB, Kusi AM, Farman C, Booler H, et al.

(10) Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degenerationScience advancesFebruary 1, 2019Kim J, Park JR, Choi J, Park I, Hwang Y, Bae H, Kim Y, Choi W, Yang JM, Han S, et al.

(11) Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retinaeLifeNovember 16, 2018Elamaa H, Kihlström M, Kapiainen E, Kaakinen M, Miinalainen I, Ragauskas S, Cerrada-Gimenez M, Mering S, Nätynki M, Eklund L.

(14) Angiopoietin-2 promotes extracellular matrix degradation in human degenerative nucleus pulposus cellsInternational journal of molecular medicineJune 1, 2018Wang K, Kang L, Liu W, Song Y, Wu X, Zhang Y, Hua W, Zhao K, Li S, Tu J, et al.

(15) IL-8 associates with a pro-angiogenic and mesenchymal subtype in glioblastomaOncotargetMarch 20, 2018Conroy S, Kruyt FAE, Wagemakers M, Bhat KPL, den Dunnen WFA.

(16) Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTPProceedings of the National Academy of Sciences of the United States of AmericaFebruary 6, 2018Souma T, Thomson BR, Heinen S, Carota IA, Yamaguchi S, Onay T, Liu P, Ghosh AK, Li C, Eremina V, et al.

(17) Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasisThe Journal of clinical investigationFebruary 1, 2018La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HS, Savant S, et al.

(18) Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactorScientific reportsJanuary 11, 2018Daly C, Qian X, Castanaro C, Pasnikowski E, Jiang X, Thomson BR, Quaggin SE, Papadopoulos N, Wei Y, Rudge JS, et al.

(20) The role of angiopoietin-2 in nucleus pulposus cells during human intervertebral disc degenerationLaboratory investigation; a journal of technical methods and pathologyAugust 1, 2017Wang K, Liu W, Song Y, Wu X, Zhang Y, Li S, Gao Y, Tu J, Liu Y, Yang C.

Angiopoietin-2 Protein