Recombinant Human gp130 Protein, CF 228-GP-010/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human gp130 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $404.00Supplier Page View Company Product Page
Catalog Number228-GP-010/CF
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in PBS and Trehalose
Size10 ug (also 50 ug)
Molecule Namegp130
NCBI Full Gene Nameinterleukin 6 cytokine family signal transducer
NCBI Gene AliasesHIES4, CD130, CDW130, sGP130, IL-6RB, GP130, IMD94, HIES4B, HIES4A, STWS2
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular Weight68 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemSf 21 (baculovirus)-derived Recombinant Human gp130 Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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1 (612) 379-2956

Fax: 1 (612) 656-4400

(1) Bmi1 Regulates IκBα Degradation via Association with the SCF ComplexJournal of immunology (Baltimore, Md. : 1950)October 15, 2018Okuyama Y, Tanaka Y, Jiang JJ, Kamimura D, Nakamura A, Ota M, Ohki T, Higo D, Ogura H, Ishii N, et al.

(2) Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor ProgressionCancer researchMay 1, 2017Tsukamoto H, Fujieda K, Hirayama M, Ikeda T, Yuno A, Matsumura K, Fukuma D, Araki K, Mizuta H, Nakayama H, et al.

(3) IL-6 trans-signaling is another pathway to upregulate OsteopontinCytokineFebruary 1, 2017Uchibori T, Matsuda K, Shimodaira T, Sugano M, Uehara T, Honda T.

(4) Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signalingScientific reportsJanuary 30, 2017Adams R, Burnley RJ, Valenzano CR, Qureshi O, Doyle C, Lumb S, Del Carmen Lopez M, Griffin R, McMillan D, Taylor RD, et al.

(5) Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase IIJournal of immunology (Baltimore, Md. : 1950)October 15, 2016Meng J, Jiang JJ, Atsumi T, Bando H, Okuyama Y, Sabharwal L, Nakagawa I, Higuchi H, Ota M, Okawara M, et al.

(6) Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-AlphaThe Journal of neuroscience : the official journal of the Society for NeuroscienceSeptember 21, 2016König C, Morch E, Eitner A, Möller C, Turnquist B, Schaible HG, Ebersberger A.

(7) The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormoneThe Journal of biological chemistryMarch 8, 2013Cho SW, Pirih FQ, Koh AJ, Michalski M, Eber MR, Ritchie K, Sinder B, Oh S, Al-Dujaili SA, Lee J, et al.

(9) Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 productionProceedings of the National Academy of Sciences of the United States of AmericaSeptember 23, 2008Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, Pakozdi A, Koch AE.

(10) Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritisArthritis and rheumatismMay 1, 2006Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, et al.

(12) Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammationImmunityJune 1, 2001Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA.

Recombinant Human gp130 Protein, CF from R&D Systems, a Bio-Techne Brand