Recombinant Human Oncostatin M (OSM) Protein 295-OM-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Oncostatin M (OSM) Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $261.00Supplier Page View Company Product Page
Catalog Number295-OM-010
SpeciesHuman
Size10 ug (also 50 ug, 250 ug, 1 mg)
Molecule NameOncostatin M/OSM
NCBI Full Gene Nameoncostatin M
FormatLyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight22 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human Oncostatin M (OSM) Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Exploring the potential of liver microphysiological systems of varied configurations to model cholestatic chemical effectsArchives of ToxicologyDecember 8, 2025Katharina S. Nitsche, Courtney Sakolish, Paul L. Carmichael, Philip Hewitt, Piyush Bajaj, Stephen S. Ferguson, Sarah M. Lloyd, Sarah S. Wilson, Hans Bouwmeester, Ivan Rusyndexamethasone (D9184, Millipore Sigma), 25 µg/mL gentamicin (1574044, ThermoFisher), and 20 ng/mL oncostatin M(295-OM-010, R&D Systems, Minneapolis, MN); it was used for pre-differentiation of iHeps according to the manufacturer’s

(2) DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated With Increased Leukemia Stem Cell FrequencyCancer DiscoveryNovember 20, 2025Thomas Köhnke, Daiki Karigane, Eleanor Hilgart, Amy C. Fan, Kensuke Kayamori, Masashi Miyauchi, Cailin T. Collins, Fabian P. Suchy, Athreya Rangavajhula, Yang Feng, et al.supplemented with Forskolin (10 μM), LIF (20 ng/mL [R&D Systems, 7734-LF-025]), OSM (10 ng/mL [R&D Systems, 295-OM-010]) and SB505124 (2 μM) for 72 hours. Hemogenic endothelium induction media was refreshed every 24 hours

(3) Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexesNature communicationsNovember 12, 2024Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC.

(4) DNMT3A(R882H) Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated With Increased Leukemia Stem Cell FrequencybioRxiv : the preprint server for biologyOctober 29, 2024Köhnke T, Karigane D, Hilgart E, Fan AC, Kayamori K, Miyauchi M, Collins CT, Suchy FP, Rangavajhula A, Feng Y, et al.supplemented with Forskolin (10 μM), LIF (20 ng/mL [R&D Systems, 7734-LF-025]), OSM (10 ng/mL [R&D Systems, 295-OM-010]) and SB505124 (2 μM) for 72 hours. Hemogenic endothelium induction media was refreshed every 24 hours

(5) Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cellsDevelopmental cellMay 6, 2024Fowler JL, Zheng SL, Nguyen A, Chen A, Xiong X, Chai T, Chen JY, Karigane D, Banuelos AM, Niizuma K, et al.supplemented with Forskolin (10 μM), LIF (20 ng/mL [R&D Systems, 7734-LF-025]), OSM (10 ng/mL [R&D Systems, 295-OM-010]), SB505124 (2 μM), and UNC1999 (1 μM [Tocris, 4904]) for 72 hours. Hemogenic endothelium induction

(6) Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMRThe Journal of biological chemistryMay 1, 2024Rafii P, Cruz PR, Ettich J, Seibel C, Padrini G, Wittich C, Lang A, Petzsch P, Köhrer K, Moll JM, et al.

(7) A RISK-BASED PRIORITIZATION OF PFAS USING PHENOTYPIC AND TRANSCRIPTOMIC DATA FROM HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED HEPATOCYTES AND CARDIOMYOCYTESALTEXFebruary 22, 2024Han-Hsuan D Doris Tsai, Lucie C. Ford, Zunwei Chen, Allison N. Dickey, Fred A. Wright, Ivan Rusyn(Cat# 15140–122) were obtained from Gibco (Waltham, MA, USA). Oncostatin-M was from R&D Systems (Cat# 295-OM-010, Minneapolis, MN, USA). For cell culture, we used tissue-culture-grade 384-well plates (for iPSC-CM,

(8) Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell CulturesCellsSeptember 27, 2023Suominen S, Hyypijev T, Venäläinen M, Yrjänäinen A, Vuorenpää H, Lehti-Polojärvi M, Räsänen M, Seppänen A, Hyttinen J, Miettinen S, et al.

(9) A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cellsStem cell reportsAugust 8, 2023Jovanovic VM, Weber C, Slamecka J, Ryu S, Chu PH, Sen C, Inman J, De Sousa JF, Barnaeva E, Hirst M, et al.

(10) Reversal of liver failure using a bioartificial liver device implanted with clinical-grade human-induced hepatocytesCell stem cellMay 4, 2023Wang Y, Zheng Q, Sun Z, Wang C, Cen J, Zhang X, Jin Y, Wu B, Yan T, Wang Z, et al.

(11) Coronary artery disease patient-derived iPSC-hepatocytes have distinct miRNA profile that may alter lipid metabolismScientific reportsJanuary 30, 2023Alexanova A, Raitoharju E, Valtonen J, Aalto-Setälä K, Viiri LE.

(12) Analysis of reproducibility and robustness of OrganoPlate® 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugsToxicology in VitroDecember 1, 2022Yuki Kato, Alicia Y. Lim, Courtney Sakolish, Alan Valdiviezo, Haley L. Moyer, Philip Hewitt, Piyush Bajaj, Gang Han, Ivan Rusyn(265005, Millipore Sigma), 25 μg/mL gentamicin (15710072, ThermoFisher), and 20 ng/mL oncostatin M (295-OM-010, R&D Systems, Minneapolis, MN); it was used for pre-differentiation of iHeps according to the manufacturer’s

(13) Induced hepatic stem cells are suitable for human hepatocyte productioniScienceOctober 21, 2022Nakashima Y, Miyagi-Shiohira C, Saitoh I, Watanabe M, Matsushita M, Tsukahara M, Noguchi H.Wako Pure Chemical Corporation, Osaka, Japan), 10 ng/mL Recombinant Human Oncostatin M (OSM) Protein (295-OM-010: R&D Systems, Minneapolis, MN), 10 μM Dexamethasone (047–18863: FUJIFILM Wako Pure Chemical Corporation,

(14) The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1ANature cell biologyOctober 1, 2022Beucher A, Miguel-Escalada I, Balboa D, De Vas MG, Maestro MA, Garcia-Hurtado J, Bernal A, Gonzalez-Franco R, Vargiu P, Heyn H, et al.ml−1 FGF-10 (ABE1324; Source BioScience) for days 7–10; and HGM medium with 30 ng ml−1 Oncostatin M (295-OM-010; R&D Systems) and 50 ng ml−1 HGF (100-39; PeproTech) for days 11–25. The definitive endoderm stage was

(15) Evaluation of Metabolism of a Defined Pesticide Mixture through Multiple In Vitro Liver ModelsToxicsSeptember 27, 2022Alan Valdiviezo, Yuki Kato, Erin S. Baker, Weihsueh A. Chiu, Ivan RusynMillipore Sigma), 25 µg/mL gentamicin (15710072, ThermoFisher), and 20 ng/mL oncostatin M (Cat No.: 295-OM-010, R&D Systems, Minneapolis, MN, USA). It was used for pre-differentiation of iHep according to the manufacturer’s

(16) High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte developmentCell reportsMarch 29, 2022Krumm J, Sekine K, Samaras P, Brazovskaja A, Breunig M, Yasui R, Kleger A, Taniguchi H, Wilhelm M, Treutlein B, et al.

(17) Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genesCell stem cellMay 6, 2021Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, et al.

(18) Formative pluripotent stem cells show features of epiblast cells poised for gastrulationCell researchMay 1, 2021Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, Sun H, Zhao ZA, Jiang X, Wang X, et al.

(19) Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS)ToxicologyJanuary 1, 2021Courtney Sakolish, Celeste E. Reese, Yu-Syuan Luo, Alan Valdiviezo, Mark E. Schurdak, Albert Gough, D. Lansing Taylor, Weihsueh A. Chiu, Lawrence A. Vernetti, Ivan Rusynpen-strep, 2 mM L-glutamine; or HPM-iPSC: RPMI, B27 (17504044, Invitrogen), 20 ng/mL Oncostatin M (295-OM-010, R&D Systems), 0.1 μM Dexamethasone (ICN19456125, MP Biomedicals, Santa Ana, CA), 25 μg/mL Gentamicin

(20) The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCsCell reportsDecember 1, 2020Michielin F, Giobbe GG, Luni C, Hu Q, Maroni I, Orford MR, Manfredi A, Di Filippo L, David AL, Cacchiarelli D, et al.

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Oncostatin M/OSM Protein

Oncostatin M/OSM Protein

Oncostatin M/OSM Protein

Recombinant Human Oncostatin M (OSM) Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Oncostatin M (OSM) Protein from R&D Systems, a Bio-Techne Brand

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