Recombinant Rat IFN-gamma Protein 585-IF-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Rat IFN-gamma Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $415.00Supplier Page View Company Product Page
Catalog Number585-IF-100
SpeciesRat
Size100 ug
Molecule NameIFN-gamma
NCBI Full Gene Nameinterferon gamma
NCBI Gene AliasesIFNG2, If2f
FormatLyophilized from a 0.2 µm filtered solution in Tris, NaCl and PEG with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight15.5 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Rat IFN-gamma Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A screen of immune signaling molecules regulated by neuronal activity identifies interferon-gamma as a modulator of synaptic function and anxiety-like behaviorBrain, behavior, and immunityNovember 1, 2025Heir R, Abuzgaya M, Adaïdi H, Franquin M, Abbasi Z, Stellwagen D.

(2) Circadian synchronization differentially modifies cytokine-mediated transcriptomic remodeling and cell death in INS-1 cells and mouse isletsiScienceMay 16, 2025Phillip Alexander Keller Andersen, Rasmus H. Reeh, Isabel Sanders, Emilie Bender Overlund, Georgia Katsioudi, Cecilia Jiménez-Sánchez, Emil Zeng Skovhøj, Anniek Frederike Lubberding, Charna Dibner, Thomas Mandrup-Poulsen15140122 Recombinant Mouse IL-1β,R&D Systems,Cat# 401-ML-005 Recombinant Rat IFN-γ,R&D Systems,Cat# 585-IF-100 "RPMI 1640 Medium, GlutaMAX™ Supplement",Thermo Fischer Scientific (Gibco™),Cat# 61870036 "RPMI 1640 Medium, GlutaMAX™ Supplement

(3) Dual role of neuroplastin in pancreatic β cells: Regulating insulin secretion and promoting islet inflammationProceedings of the National Academy of Sciences of the United States of AmericaAugust 13, 2024Kitamura RA, Hummel D, Ustione A, Piston DW, Urano F.

(4) A TLR4 Agonist Induces Osteosarcoma Regression by Inducing an Antitumor Immune Response and Reprogramming M2 Macrophages to M1 MacrophagesCancersSeptember 19, 2023Richert I, Berchard P, Abbes L, Novikov A, Chettab K, Vandermoeten A, Dumontet C, Karanian M, Kerzerho J, Caroff M, et al.

(5) Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin bindingCell death & diseaseJuly 5, 2023Urizar AI, Prause M, Ingerslev LR, Wortham M, Sui Y, Sander M, Williams K, Barrès R, Larsen MR, Christensen GL, et al.

(6) BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced ApoptosisInternational journal of molecular sciencesMarch 16, 2023Perez-Serna AA, Dos Santos RS, Ripoll C, Nadal A, Eizirik DL, Marroqui L.

(7) Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injuryMolecular painJanuary 1, 2023Asano S, Okada-Ogawa A, Kobayashi M, Yonemoto M, Hojo Y, Shibuta I, Noma N, Iwata K, Hitomi S, Shinoda M.

(8) High-Throughput Analysis of Astrocyte Cultures Shows Prevention of Reactive Astrogliosis by the Multi-Nutrient Combination Fortasyn ConnectCellsApril 22, 2022Badia-Soteras A, de Vries J, Dykstra W, Broersen LM, Verkuyl JM, Smit AB, Verheijen MHG.

(9) Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-CellsFrontiers in endocrinologyJanuary 1, 2022Morikawa S, Blacher L, Onwumere C, Urano F.(Corning, Cat# 25-060-CI), and 100 U/mL penicillin-streptomycin. Rat IFN-γ, rat IL-1β (R&D Systems, Cat# 585-IF-100, 501-RL-010), and thapsigargin (MilliporeSigma, Cat# T9033) were used for the treatments. Wolfram Syndrome

(10) Substratum interactions determine immune response to allogeneic transplants of endothelial cellsFrontiers in immunologyJanuary 1, 2022Wilcox EC, Edelman ER.R211-500). Cytokine treated cells were incubated with media supplemented with 40 ng/ml IFNγ (R&D systems, 585-IF-100) and 25 ng/ml TNFα (R&D systems, 510-RT-010) for 48 hours before isolating RNA. All cells were used

(11) Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetesCell reportsAugust 24, 2021Javeed N, Her TK, Brown MR, Vanderboom P, Rakshit K, Egan AM, Vella A, Lanza I, Matveyenko AV.

(12) Astrocytes Stimulate Microglial Proliferation and M2 Polarization In Vitro through Crosstalk between Astrocytes and MicrogliaInternational journal of molecular sciencesAugust 16, 2021Kim S, Son Y.

(13) IFNγ-stimulated dendritic cell extracellular vesicles can be nasally administered to the brain and enter oligodendrocytesPloS oneJanuary 1, 2021Pusic KM, Kraig RP, Pusic AD.

(14) Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophagesNature communicationsOctober 16, 2020Wang Y, Sangaré LO, Paredes-Santos TC, Hassan MA, Krishnamurthy S, Furuta AM, Markus BM, Lourido S, Saeij JPJ.plates (1 × 105 cells/well) were stimulated with 1 ng/mL or 5 ng/mL murine or rat IFNγ (R&D System, Cat#585-IF-100) for 24 h followed by infection with wild-type luciferase-expressing parasites or knockout parasites

(15) Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in MiceFrontiers in endocrinologyJanuary 1, 2020Petrovic I, Pejnovic N, Ljujic B, Pavlovic S, Miletic Kovacevic M, Jeftic I, Djukic A, Draginic N, Andjic M, Arsenijevic N, et al.

(16) Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cellsCell death & diseaseApril 5, 2019Vig S, Buitinga M, Rondas D, Crèvecoeur I, van Zandvoort M, Waelkens E, Eizirik DL, Gysemans C, Baatsen P, Mathieu C, et al.donors are provided in Supplementary Table S1. INS-1E cells were exposed to recombinant rat IFN-γ (# 585-IF-100, 500 U/ml; R&D Systems, Minneapolis, MN, USA) and human IL-1β (# 201-LB-005, 10 U/ml; hIL-1β; R&D Systems).

(17) Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axonsPLOS PathogensJuly 20, 2018Margaret A. MacGibeny, Orkide O. Koyuncu, Christoph Wirblich, Matthias J. Schnell, Lynn W. Enquistprior to infection unless other timing is specified. Recombinant rat IFN-gamma protein (R&D Systems; 585-IF-100) and recombinant rat IFN-beta (PBL Assay Science; 13400–1) were used at 500 U/ml (retrograde infection)

(18) Prolactin protects against cytokine-induced beta-cell death by NFκB and JNK inhibitionJournal of molecular endocrinologyJuly 1, 2018Nardelli TR, Vanzela EC, Benedicto KC, Brozzi F, Fujita A, Cardozo AK, Eizirik DL, Boschero AC, Ortis F.

(19) Analytical performance of a commercial multiplex Luminex-based cytokine panel in the ratJournal of pharmacological and toxicological methodsMay 1, 2018Erkens T, Goeminne N, Kegels A, Byloos M, Vinken P.

(20) Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosisCell death & diseaseJanuary 24, 2018Lambelet M, Terra LF, Fukaya M, Meyerovich K, Labriola L, Cardozo AK, Allagnat F.

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Recombinant Rat IFN-gamma Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Rat IFN-gamma Protein from R&D Systems, a Bio-Techne Brand

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