Recombinant Human NRG1-alpha/HRG1-alpha EGF Domain Protein 296-HR-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human NRG1-alpha/HRG1-alpha EGF Domain Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $415.00Supplier Page View Company Product Page
Catalog Number296-HR-050
Size50 ug
ApplicationsBioactivity
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 8 kDa, reducing conditions
Theoretical: 7 kDa
Conjugate/TagUnconjugated
SpeciesHuman
Molecule NameNeuregulin-1 alpha/NRG1 alpha
Source/Expression SystemE. coli-derived Recombinant Human NRG1-alpha/HRG1-alpha EGF Domain Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Nameneuregulin 1
NCBI Gene AliasesARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A novel anti-HER2 antibody GB235 reverses Trastuzumab resistance in HER2-expressing tumor cells in vitro and in vivoScientific reportsFebruary 19, 2020Shu M, Yan H, Xu C, Wu Y, Chi Z, Nian W, He Z, Xiao J, Wei H, Zhou Q, et al.

(2) Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasisJCI insightOctober 18, 2018Brand JD, Lazrak A, Trombley JE, Shei RJ, Adewale AT, Tipper JL, Yu Z, Ashtekar AR, Rowe SM, Matalon S, et al.by adding 10 nM recombinant human neuregulin-1α/epidermal growth factor-like domain of heregulin-α (296-HR-050, R&D Systems) to the basolateral ALI media. After approximately 2 weeks of exposure to air, cells demonstrated

(3) Neuregulin-1 is a chemoattractant and chemokinetic molecule for trunk neural crest cellsDevelopmental dynamics : an official publication of the American Association of AnatomistsJuly 1, 2018De Bellard ME, Ortega B, Sao S, Kim L, Herman J, Zuhdi N.(200 ng/ml) and NRG1β (20 ng/ml) refer to NRG1 EGF-like domains from R&D Systems (Minneapolis, MN; #296-HR-050 and #396-HB-050/CF, respectively). Fibronectin was 10 μg/ml. A Zeiss Axiovert 35M was used for non-fluorescence imaging

(4) Modulation of the Neuregulin 1/ErbB system after skeletal muscle denervation and reinnervationScientific reportsMarch 22, 2018Morano M, Ronchi G, Nicolò V, Fornasari BE, Crosio A, Perroteau I, Geuna S, Gambarotta G, Raimondo S.

(5) Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4Molecular and cellular neurosciencesDecember 1, 2016Fornasari BE, El Soury M, De Marchis S, Perroteau I, Geuna S, Gambarotta G.

(6) Neuregulin-1 attenuates mortality associated with experimental cerebral malariaJournal of neuroinflammationJanuary 17, 2014Solomon W, Wilson NO, Anderson L, Pitts S, Patrickson J, Liu M, Ford BD, Stiles JK.

(7) HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in miceCancer gene therapyDecember 1, 2012MacLeod SH, Elgadi MM, Bossi G, Sankar U, Pisio A, Agopsowicz K, Sharon D, Graham FL, Hitt MM.

(8) Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitorsNatureJuly 26, 2012Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, et al.

(9) EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastasesThe Journal of biological chemistrySeptember 14, 2007Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L.

(10) Neuregulin1 (NRG1) Signaling through Fyn Modulates NMDA Receptor Phosphorylation: Differential Synaptic Function in NRG1+/- Knock-Outs Compared with Wild-Type MiceJournal of NeuroscienceApril 25, 2007Maria Bjarnadottir, Dinah L Misner, Sascha Haverfield-Gross, Silas Bruun, Vignir G Helgason, Hreinn Stefansson, Arnar Sigmundsson, David R Firth, Berit Nielsen, Ragnheidur Stefansdottir, et al.(EGF) domain [amino acids 177–241; Reference Sequence (RefSeq) accession number NP_039258] (catalog #296-HR-050; R & D Systems, Minneapolis, MN) was used for all biochemical assays. NRG1 stimulation was performed

(11) Identification of neuregulin as a factor required for formation of aligned spermatogoniaThe Journal of biological chemistryJanuary 5, 2007Hamra FK, Chapman KM, Nguyen D, Garbers DL.

(12) A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactionsProceedings of the National Academy of Sciences of the United States of AmericaDecember 12, 2006Wehrman TS, Raab WJ, Casipit CL, Doyonnas R, Pomerantz JH, Blau HM.

(13) Prolactin and heregulin override DNA damage-induced growth arrest and promote phosphatidylinositol-3 kinase-dependent proliferation in breast cancer cellsInternational journal of oncologyFebruary 1, 2005Chakravarti P, Henry MK, Quelle FW.

(14) Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic strokeBiochemical and biophysical research communicationsSeptember 17, 2004Xu Z, Jiang J, Ford G, Ford BD.

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Recombinant Human NRG1-alpha/HRG1-alpha EGF Domain Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human NRG1-alpha/HRG1-alpha EGF Domain Protein from R&D Systems, a Bio-Techne Brand

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