Recombinant Human TrkC Fc Chimera Protein 373-TC-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human TrkC Fc Chimera Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $454.00Supplier Page View Company Product Page
Catalog Number373-TC-050
SpeciesHuman
Molecule NameTrkC
Size50 ug
NCBI Full Gene Nameneurotrophic receptor tyrosine kinase 3
NCBI Gene AliasesGP145-TrkC, TRKC, gp145(trkC)
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 130-150 kDa, reducing conditions
Theoretical: 72 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human TrkC Fc Chimera Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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(2) Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutationsProceedings of the National Academy of Sciences of the United States of AmericaApril 18, 2017Sleigh JN, Dawes JM, West SJ, Wei N, Spaulding EL, Gómez-Martín A, Zhang Q, Burgess RW, Cader MZ, Talbot K, et al.

(3) Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signalingNature neuroscienceJanuary 1, 2011Vaegter CB, Jansen P, Fjorback AW, Glerup S, Skeldal S, Kjolby M, Richner M, Erdmann B, Nyengaard JR, Tessarollo L, et al.

(4) Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosisThe Journal of clinical investigationMarch 1, 2010Bouzas-Rodriguez J, Cabrera JR, Delloye-Bourgeois C, Ichim G, Delcros JG, Raquin MA, Rousseau R, Combaret V, Bénard J, Tauszig-Delamasure S, et al.

(6) Rapid axoglial signaling mediated by neuregulin and neurotrophic factorsThe Journal of neuroscience : the official journal of the Society for NeuroscienceJuly 7, 2004Esper RM, Loeb JA.

Recombinant Human TrkC Fc Chimera Protein from R&D Systems, a Bio-Techne Brand