IL-7R alpha/CD127 Fc Chimera Protein 306-IR-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-7R alpha/CD127 Fc Chimera Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $465.00Supplier Page View Company Product Page
Catalog Number306-IR-050
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in PBS
Size50 ug
Molecule NameIL-7R alpha/CD127
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 80-90 kDa, reducing conditions
Theoretical: 54.5 kDa (monomer)
ApplicationsBinding Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human IL-7R alpha/CD127 Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Nameinterleukin 7 receptor
NCBI Gene AliasesCD127, CDW127, IL-7R-alpha, IL-7Ralpha, IL7RA, IL7Ralpha, ILRA, IMD104, lnc-IL7R, sIL-7R

Specifications/Features

Available conjugates: Sizes Available: 50 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Antisense modulation of IL7R splicing to control sIL7R expression in human CD4(+) T cellsRNA (New York, N.Y.)August 1, 2022Galarza-Muñoz G, Kennedy-Boone D, Schott G, Bradrick SS, Garcia-Blanco MA.

(2) Interleukin-7-dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetesEuropean journal of immunologyDecember 1, 2021Hehenkamp P, Hoffmann M, Kummer S, Reinauer C, Döing C, Förtsch K, Enczmann J, Balz V, Mayatepek E, Meissner T, et al.

(3) Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine ProteasesFrontiers in immunologyJanuary 1, 2021Vandooren J, Pereira RVS, Ugarte-Berzal E, Rybakin V, Noppen S, Stas MR, Bernaerts E, Ganseman E, Metzemaekers M, Schols D, et al.Supplementary Table 1 ). The IL-7 receptor ectodomain was purchased from R&D Systems (rhIL-7, cat. no. 306-IR-050). Recombinant human MMP-9 was produced, purified, activated and tested as described (27). Recombinant

(4) Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk alleleNature communicationsOctober 8, 2019Al-Mossawi H, Yager N, Taylor CA, Lau E, Danielli S, de Wit J, Gilchrist J, Nassiri I, Mahe EA, Lee W, et al.

(5) Interleukin-7 receptor α-chain haplotypes differentially affect soluble IL-7 receptor and IL-7 serum concentrations in children with type 1 diabetesPediatric diabetesAugust 1, 2018Seyfarth J, Lundtoft C, Förtsch K, Ahlert H, Rosenbauer J, Baechle C, Roden M, Holl RW, Mayatepek E, Kummer S, et al.

(6) Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosisPLoS pathogensJune 1, 2017Lundtoft C, Afum-Adjei Awuah A, Rimpler J, Harling K, Nausch N, Kohns M, Adankwah E, Lang F, Olbrich L, Mayatepek E, et al.

(7) Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis RiskCellMarch 23, 2017Galarza-Muñoz G, Briggs FBS, Evsyukova I, Schott-Lerner G, Kennedy EM, Nyanhete T, Wang L, Bergamaschi L, Widen SG, Tomaras GD, et al.of samples was extrapolated from standard curves of recombinant human IL7R-Fc chimera (R&D Systems, 306-IR-050). Given that knockdown of DDX39B increases skipping of IL7R exon 6, we expected secretion of sIL7R to

(8) Reduced plasma levels of soluble interleukin-7 receptor during graft-versus-host disease (GVHD) in children and adultsBMC immunologyJune 19, 2014Poiret T, Rane L, Remberger M, Omazic B, Gustafsson-Jernberg A, Vudattu NK, Ahmed R, Ernberg I, Winiarski J, Magalhaes I, et al.

(9) IL-7 restores lymphocyte functions in septic patientsJournal of immunology (Baltimore, Md. : 1950)November 15, 2012Venet F, Foray AP, Villars-Méchin A, Malcus C, Poitevin-Later F, Lepape A, Monneret G.

(10) Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patientsGenes and immunityOctober 1, 2012Kreft KL, Verbraak E, Wierenga-Wolf AF, van Meurs M, Oostra BA, Laman JD, Hintzen RQ.

(11) Soluble HIV Tat protein removes the IL-7 receptor alpha-chain from the surface of resting CD8 T cells and targets it for degradationJournal of immunology (Baltimore, Md. : 1950)September 1, 2010Faller EM, Sugden SM, McVey MJ, Kakal JA, MacPherson PA.

(12) Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patientsJournal of immunology (Baltimore, Md. : 1950)June 15, 2009Rose T, Lambotte O, Pallier C, Delfraissy JF, Colle JH.

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IL-7R alpha/CD127 Fc Chimera Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (12)

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IL-7R alpha/CD127 Fc Chimera Protein from R&D Systems, a Bio-Techne Brand

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