Recombinant Mouse NKG2D Fc Chimera Protein, CF 139-NK-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse NKG2D Fc Chimera Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $479.00Supplier Page View Company Product Page
Catalog Number139-NK-050
SpeciesMouse
Size50 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS
Molecule NameNKG2D/CD314
NCBI Full Gene Namekiller cell lectin-like receptor subfamily K, member 1
NCBI Gene AliasesNkg2d, D6H12S2489E, NKG2-D
Purity>85%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 55-60 kDa, reducing conditions
Theoretical: 42.7 kDa (monomer)
ApplicationsBinding Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Mouse NKG2D Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A vaccine targeting resistant tumours by dual T cell plus NK cell attackNatureJune 1, 2022Badrinath S, Dellacherie MO, Li A, Zheng S, Zhang X, Sobral M, Pyrdol JW, Smith KL, Lu Y, Haag S, et al.1299-NK-050, R&D Systems) or with recombinant mouse NKG2D–Fc chimera protein (10 μg ml−1 in FACS buffer; 139-NK-050, R&D Systems) for 1 h on ice. Cells were washed twice with FACS buffer and stained with 100 μl Alexa

(2) Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer ImmunotherapyJournal of immunology (Baltimore, Md. : 1950)July 1, 2021Banerjee A, Li D, Guo Y, Mahgoub B, Paragas L, Slobin J, Mei Z, Manafi A, Hata A, Li K, et al.of WT IL-2, mutIL-2, and OMCPmutIL-2 for murine CD25 (#2438-RM, R&D systems) and murine NKG2D-Fc (#139-NK-050, R&D systems). All experiments were carried out at a flow rate of 100 μl/min, 26°C, and in ProteOn PBS/Tween

(3) Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular CytotoxicityJournal of virologyAugust 15, 2017Alsahafi N, Richard J, Prévost J, Coutu M, Brassard N, Parsons MS, Kaufmann DE, Brockman M, Finzi A.

(4) TLR9 Regulates the NF-κB-NLRP3-IL-1β Pathway Negatively in Salmonella-Induced NKG2D-Mediated Intestinal InflammationJournal of immunology (Baltimore, Md. : 1950)July 15, 2017Li Y, Liu M, Zuo Z, Liu J, Yu X, Guan Y, Zhan R, Han Q, Zhang J, Zhou R, et al.

(5) The MICA-129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantationEMBO molecular medicineNovember 1, 2015Isernhagen A, Malzahn D, Viktorova E, Elsner L, Monecke S, von Bonin F, Kilisch M, Wermuth JM, Walther N, Balavarca Y, et al.

(6) T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in MiceMolecular therapy : the journal of the American Society of Gene TherapyOctober 1, 2015VanSeggelen H, Hammill JA, Dvorkin-Gheva A, Tantalo DG, Kwiecien JM, Denisova GF, Rabinovich B, Wan Y, Bramson JL.

(7) TL1A regulates TCRγδ+ intraepithelial lymphocytes and gut microbial compositionEuropean journal of immunologyMarch 1, 2015Tougaard P, Skov S, Pedersen AE, Krych L, Nielsen DS, Bahl MI, Christensen EG, Licht TR, Poulsen SS, Metzdorff SB, et al.

(8) The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinomaInternational journal of cancerJune 15, 2014Rothe A, Jachimowicz RD, Borchmann S, Madlener M, Keßler J, Reiners KS, Sauer M, Hansen HP, Ullrich RT, Chatterjee S, et al.

(9) MULT1E/mIL-12: a novel bifunctional protein for natural killer cell activationGene therapyMay 1, 2014Tietje A, Li J, Yu X, Wei Y.

(10) CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1ε transgenic miceImmunologyMarch 1, 2014Lin Z, Wang C, Xia H, Liu W, Xiao W, Qian L, Jia X, Ding Y, Ji M, Gong W.

(11) Alloimmune activation promotes anti-cancer cytotoxicity after rat liver transplantationPloS oneJanuary 1, 2014Lacotte S, Oldani G, Slits F, Orci LA, Rubbia-Brandt L, Morel P, Mentha G, Toso C.transplantation. doi:10.1371/journal.pone.0091515.g003 RH7777 cell lines after incubation with mouse recombinant NKG2D-Fc chimera (139-NK-050, R&D Systems)(5 mg/well) and anti-human IgG Fc (HP6017, Biolegend). The level of anti-cancer cell cytotoxicity

(12) Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1γ reveals a paradigm for MHC/MHC interaction in immune evasionProceedings of the National Academy of Sciences of the United States of AmericaDecember 18, 2012Wang R, Natarajan K, Revilleza MJ, Boyd LF, Zhi L, Zhao H, Robinson H, Margulies DH.

(13) Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repairJournal of immunology (Baltimore, Md. : 1950)April 15, 2012Yoshida S, Mohamed RH, Kajikawa M, Koizumi J, Tanaka M, Fugo K, Otsuka N, Maenaka K, Yagita H, Chiba H, et al.

(14) Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cellsNature immunologySeptember 1, 2009Dong Z, Cruz-Munoz ME, Zhong MC, Chen R, Latour S, Veillette A.

(15) Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillanceCancer researchJuly 1, 2009Dibra D, Cutrera JJ, Xia X, Birkenbach MP, Li S.

(16) Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activityJournal of molecular biologyDecember 31, 2008Kwong KY, Baskar S, Zhang H, Mackall CL, Rader C.

(17) Tumor cells expressing a fusion protein of MULT1 and Fas are rejected in vivo by apoptosis and NK cell activationGene therapyOctober 1, 2008Kotturi HS, Li J, Branham-O'Connor M, Stickel SL, Yu X, Wagner TE, Wei Y.

(18) Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillanceProceedings of the National Academy of Sciences of the United States of AmericaFebruary 5, 2008Unni AM, Bondar T, Medzhitov R.

(19) Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2DJournal of immunology (Baltimore, Md. : 1950)February 1, 2008Takada A, Yoshida S, Kajikawa M, Miyatake Y, Tomaru U, Sakai M, Chiba H, Maenaka K, Kohda D, Fugo K, et al.

(20) Chimeric NKG2D receptor-bearing T cells as immunotherapy for ovarian cancerCancer researchMay 15, 2007Barber A, Zhang T, DeMars LR, Conejo-Garcia J, Roby KF, Sentman CL.

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Recombinant Mouse NKG2D Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse NKG2D Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

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