P-Selectin/CD62P Fc Chimera Protein 137-PS-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemP-Selectin/CD62P Fc Chimera Protein
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number137-PS-050
SpeciesHuman
Quantity50 ug
Molecule NameP-Selectin/CD62P
FormatLyophilized from a 0.2 µm filtered solution in PBS
NCBI Full Gene Nameselectin P
NCBI Gene AliasesPADGEM, CD62, GMP140, PSEL, CD62P, GRMP, LECAM3
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 146-160 kDa, reducing conditions
Theoretical: 106 kDa (monomer)
Brand/TrademarkR&D Systems, a Bio-Techne Brand
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human P-Selectin/CD62P Fc Chimera Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Oligomer-guided recognition of two fucan sulfate from Bohadschia argus and inhibition of P-selectin binding to its ligandCarbohydrate polymersOctober 1, 2023Ruzemaimaiti D, Sun H, Zhang J, Xu C, Chen L, Yin R, Zhao J.

(2) T helper 1 effector memory CD4(+) T cells protect the skin from poxvirus infectionCell reportsMay 30, 2023Harbour JC, Abdelbary M, Schell JB, Fancher SP, McLean JJ, Nappi TJ, Liu S, Nice TJ, Xia Z, Früh K, et al.

(3) An isoform of the giant protein titin is a master regulator of human T lymphocyte traffickingCell reportsMay 30, 2023Toffali L, D'Ulivo B, Giagulli C, Montresor A, Zenaro E, Delledonne M, Rossato M, Iadarola B, Sbarbati A, Bernardi P, et al.

(4) Adhesion analysis via a tumor vasculature-like microfluidic device identifies CD8(+) T cells with enhanced tumor homing to improve cell therapyCell reportsMarch 28, 2023Camargo CP, Muhuri AK, Alapan Y, Sestito LF, Khosla M, Manspeaker MP, Smith AS, Paulos CM, Thomas SN.ICAM Fc Chimera,R&D Systems,Cat#796-IC-050 Recombinant Human P-selectin Fc Chimera,R&D Systems,Cat#137-PS-050 "Polydimethylsiloxane (PDMS), Dow Corning Sylgard 184",Ellsworth Adhesives,"Cat#184 SIL ELAST KIT 3.9KG,

(5) The effect of type-2 diabetes conditions on neutrophil rolling adhesionBMC research notesDecember 3, 2022Taverner K, Murad Y, Yasunaga AB, Furrer C, Little J, Li ITS.

(6) Structural characterization and antagonistic effect against P-selectin-mediated function of SFF-32, a fucoidan fraction from Sargassum fusiformeJournal of ethnopharmacologySeptember 15, 2022Wu S, Liu J, Zhang Y, Song J, Zhang Z, Yang Y, Wu M, Tong H.

(7) A humanized β(2) integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in vivoCell reportsMay 31, 2022Wen L, Marki A, Wang Z, Orecchioni M, Makings J, Billitti M, Wang E, Suthahar SSA, Kim K, Kiosses WB, et al.proteins","Chemicals, peptides, and recombinant proteins" ,, Recombinant human P-selectin-Fc,R&D Systems,Cat# 137-PS-050 Recombinant human ICAM-1-Fc,R&D Systems,Cat# 720-IC-050 Recombinant human IL-8,R&D Systems,Cat# 208-IL-010 Recombinant

(8) P-selectin glycoprotein ligand-1 (PSGL-1/CD162) is incorporated into clinical HIV-1 isolates and can mediate virus capture and subsequent transfer to permissive cellsRetrovirologyMay 21, 2022Burnie J, Persaud AT, Thaya L, Liu Q, Miao H, Grabinsky S, Norouzi V, Lusso P, Tang VA, Guzzo C.tissue culture plates were coated overnight at 4 °C with 5 μg/mL recombinant P-selectin (R&D Systems, #137-PS-050) or MAdCAM-1 (R&D Systems, #6056-MC-050) proteins. The following day the wells were washed 3X with PBS

(9) Mitofusin-2 regulates leukocyte adhesion and β2 integrin activationJournal of leukocyte biologyApril 1, 2022Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, et al.

(10) Lung-Derived Selectins Enhance Metastatic Behavior of Triple Negative Breast Cancer CellsBiomedicinesOctober 30, 2021Khan SU, Xia Y, Goodale D, Schoettle G, Allan AL.

(11) Quantification of fast molecular adhesion by fluorescence footprintingScience advancesAugust 1, 2021Yasunaga AB, Li ITS.9048-46-8), streptavidin (Cedarlane, CL1005-01-5MG), TGT-biot-PG, and P-selectin Fc chimera (R&D Systems, 137-PS-050). BSA (10 mg/ml) was flowed into the chamber and incubated for 15 min to further passivate the PEGylated

(12) Efficient inhibition of O-glycan biosynthesis using the hexosamine analog Ac₅GalNTGcCell chemical biologyMay 20, 2021Wang SS, Solar VD, Yu X, Antonopoulos A, Friedman AE, Agarwal K, Garg M, Ahmed SM, Addhya A, Nasirikenari M, et al.7138 L-selectin,R&D Systems,728-LS-100 E-selectin,R&D Systems,724-ES-100 P-selectin,R&D Systems,137-PS-050 IL-1β,R&D Systems,201-LB-025/CF Peracetylated HexNAc compounds,"Agarwal, K., et al. J. Am. Chem. Soc.

(13) Super-STORM: Molecular Modeling to Achieve Single-molecule Localization with STORM MicroscopySTAR protocolsJune 19, 2020Fan Z, Mikulski Z, McArdle S, Sundd P, Ley K.Proteins","Chemicals, Peptides, and Recombinant Proteins" ,, Recombinant human P-selectin-Fc,R&D Systems,Cat# 137-PS-050 Recombinant human ICAM-1 -Fc,R&D Systems,Cat# 720-IC-050 Recombinant human IL-8,R&D Systems,Cat# 208-IL-010 Recombinant

(14) Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rollingJournal of leukocyte biologyFebruary 1, 2020Sun H, Fan Z, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K.

(15) Doxycycline-Dependent Self-Inactivation of CRISPR-Cas9 to Temporally Regulate On- and Off-Target EditingMolecular therapy : the journal of the American Society of Gene TherapyJanuary 8, 2020Kelkar A, Zhu Y, Groth T, Stolfa G, Stablewski AB, Singhi N, Nemeth M, Neelamegham S.

(16) The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endotheliumPloS oneJanuary 1, 2020Lam FW, Brown CA, Valladolid C, Emebo DC, Palzkill TG, Cruz MA.

(17) Selectin Binding Sites Are Involved in Cell Adhesive Properties of Head and Neck Squamous Cell CarcinomaCancersOctober 28, 2019Valentiner U, Knips J, Pries R, Clauditz T, Münscher A, Sauter G, Wollenberg B, Schumacher U.

(18) CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicityNature communicationsSeptember 25, 2019Fu W, Lei C, Liu S, Cui Y, Wang C, Qian K, Li T, Shen Y, Fan X, Lin F, et al.

(19) Dynamic biochemical tissue analysis detects functional selectin ligands on human cancer tissuesScientific reportsJune 11, 2019Martin EW, Malgor R, Resto VA, Goetz DJ, Burdick MM.

(20) Central memory CD8+ T cells become CD69+ tissue-residents during viral skin infection independent of CD62L-mediated lymph node surveillancePLoS pathogensMarch 1, 2019Osborn JF, Hobbs SJ, Mooster JL, Khan TN, Kilgore AM, Harbour JC, Nolz JC.

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P-Selectin/CD62P Fc Chimera Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (50)

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P-Selectin/CD62P Fc Chimera Protein from R&D Systems, a Bio-Techne Brand

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