Description
Ceruloplasmin is a blue, copper binding glycoprotein involved in the peroxidation of Fe2+ transferrin to Fe3+ transferrin, without releasing radical oxygen species. It is an acute-phase reactant. Increased levels are associated with normal pregnancy, rheumatoid arthritis, and cirrhosis. Decreased levels are associated with hepatolenticular degeneration (Wilson's Disease). An elevated level of Cp is found in patients with progressive tumors. Additionally, because Cp is a prooxidant, an elevated level is a sign of cardiovascular disease. May also play a role in fetal lung development or pulmonary antioxidant defense