Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate
CompanyR&D Systems, a Bio-Techne Brand
Price $562.00Supplier Page View Company Product Page
Catalog NumberES001
Quantity1 mg
ApplicationsBioactivity, Binding Activity
Molecular Weight1093 Da
SpeciesMulti-Species
Molecule NameProtease Substrates
ImmunogenMca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
StorageSamples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Discovery of an APP-selective BACE1 inhibitor for Alzheimer's diseaseNeurotherapeuticsSeptember 1, 2025Jesus Campagna, Barbara Jagodzinska, Dongwook Wi, Chunni Zhu, Jessica Lee, Whitaker Cohn, Michael Jun, Chris Elias, Samar Padder, Olivier Descamps, et al.(CatD) activity was assessed using the R&D Systems CatD activity assay kit (Catalog #: 1014-AS and ES001) according to the manufacturer's instructions. For the assay, 4 μL of assay buffer was added to each

(2) Interactions of substrates and phosphinyl containing inhibitors with bacterial and human zinc proteasesPLoS OneAugust 1, 2025Fatema Amatur Rahman, Imin Wushur, Ida Kristine Østnes Hansen, Tor Haug, Klara Stensvåg, Bibek Chaulagain, Tra-Mi Nguyen, Olayiwola Adedotun Adekoya, Nabin Malla, Jan-Olof Winberg, et al.PLN were from Calbiochem (San Diego, CA, USA), while ALN was from BioCentrum Ltd (Kraków, Poland). ES001 and ES005 were from R&D Systems (Minneapolis, MN, USA). Mca-PL-OH was from Bachem AG (Basel, Switzerland).

(3) Altered extracellular matrix structure and elevated stiffness in a brain organoid model for diseaseNat CommunMay 1, 2025Maayan Karlinski Zur, Bidisha Bhattacharya, Inna Solomonov, Sivan Ben Dror, Alon Savidor, Yishai Levin, Amir Prior, Tamar Sapir, Talia Harris, Tsviya Olender, et al.in a 96-well plate with different concentrations of Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate (ES001, R&D SYSTEMS), a substrate that is cleaved by MMP9. The peptide substrate contains a highly fluorescent

(4) Discovery of a new class of cell-penetrating peptides by novel phage display platformScientific ReportsJune 11, 2024Jinsha Liu, John Heddleston, Douglas Raymond Perkins, Jack Jia Hua Chen, Ahmadreza Ghanbarpour, Bill William Smith, Rebecca Miles, Eitaro Aihara, Sepideh Afsharcathepsin B/L (Cat. No. ES008, R&D Systems), cathepsin C (Cat. No. I-1215, Bachem), cathepsin D (Cat. No. ES001, R&D Systems), cathepsin H (Cat. No. 05859, Chemimpex), and cathepsin S (Cat. No. ES002, R&D Systems).

(5) Expression, purification and refolding of pro-MMP-2 from inclusion bodies of E. coliProtein expression and purificationAugust 1, 2023Zhang YN, Liu JJ, Zhang W, Qin HY, Wang LT, Chen YY, Yuan L, Yang F, Cao RY, Wang XJ.

(6) Functional and Proteomic Insights into Aculeata VenomsToxinsMarch 16, 2023Dashevsky D, Baumann K, Undheim EAB, Nouwens A, Ikonomopoulou MP, Schmidt JO, Ge L, Kwok HF, Rodriguez J, Fry BG.buffer and substrate only. For testing on Mca-PLGL-Dpa-AR-NH2 fluorogenic peptide substrate (Cat. # ES001, R&D systems, Minneapolis, Minnesota), 10 μL of 0.05 μg/μL venom stock was plated in triplicate on a

(7) Ageing-Induced Decline in Primary Myeloid Cell Phagocytosis Is Unaffected by Optineurin InsufficiencyBiologyFebruary 3, 2023Peradinovic J, Mohovic N, Bulic K, Markovinovic A, Cimbro R, Munitic I.Mouse IL-10 DuoSet ELISA (#RD-DY417) from R&D systems (Minneapolis, MN, USA) and 3,3′,5,5′-Tetrametilbenzidine (TMB, #ES001) from Merck Millipore (Burlington, MA, USA). 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES,

(8) Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc MetalloproteasesMolecules (Basel, Switzerland)December 22, 2021Rahman F, Wushur I, Malla N, Åstrand OAH, Rongved P, Winberg JO, Sylte I.(San Diego, CA, USA) and Aureolysin was from BioCentrum Ltd. (Kraków, Poland). McaPLGL(Dpa)AR-NH2 (ES001) and McaRPPGFSAFK(Dnp)-OH (ES005) were from R&D Systems (Minneapolis, MN, USA). 3.2. Compounds for

(9) A Genus-Wide Bioactivity Analysis of Daboia (Viperinae: Viperidae) Viper Venoms Reveals Widespread Variation in Haemotoxic PropertiesInternational journal of molecular sciencesDecember 15, 2021Op den Brouw B, Coimbra FCP, Casewell NR, Ali SA, Vonk FJ, Fry BG.Venom Metalloprotease (SVMP) and Serine Protease (SVSP) Activity Fluorogenic Peptide Substrates Cat#ES001, Cat#ES002, and Cat#ES0011 (R&D systems, Minneapolis, MN, USA) were used to test for SVMP, SVMP/SVSP,

(10) Inhibition of bacterial and human zinc-metalloproteases by bisphosphonate- and catechol-containing compoundsJournal of enzyme inhibition and medicinal chemistryDecember 1, 2021Rahman F, Nguyen TM, Adekoya OA, Campestre C, Tortorella P, Sylte I, Winberg JO.Calbiochem (San Diego, CA, USA) and Aureolysin was from BioCentrum Ltd (Kraków, Poland). McaPLGL(Dpa)AR-NH2 (ES001) and McaRPPGFSAFK(Dnp)-OH (ES005) were from R&D Systems (Minneapolis, MN, USA). Synthesis of compounds Synthesis

(11) Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamicsCellular oncology (Dordrecht)December 1, 2021Keum S, Yang SJ, Park E, Kang T, Choi JH, Jeong J, Hwang YE, Kim JW, Park D, Rhee S.Next, the supernatants were incubated with 10 µM fluorogenic MMP substrates (Mca-PLGL-Dpa-AR-NH2; #ES001; R&D Systems, Minneapolis, MN, USA) for 2 h at 37 °C. The fluorescence signals of samples were measured

(12) Pharmacological Characterisation of Pseudocerastes and Eristicophis Viper Venoms Reveal Anticancer (Melanoma) Properties and a Potentially Novel Mode of FibrinogenolysisInternational Journal of Molecular SciencesJune 27, 2021Bianca op den Brouw, Parviz Ghezellou, Nicholas R. Casewell, Syed Abid Ali, Behzad Fathinia, Bryan G. Fry, Mettine H.A. Bos, Maria P. Ikonomopoulouquenched substrate was automatically dispensed (10 µL substrate (Fluorogenic Peptide Substrate Cat#ES001; R&D systems, Minneapolis, MN, USA)) in 5 mL enzyme buffer (150 mM NaCl, 50 mM Tris-HCl, 5 mM CaCl2

(13) Predicting Proteolysis in Complex Proteomes Using Deep LearningInternational journal of molecular sciencesMarch 17, 2021Ozols M, Eckersley A, Platt CI, Stewart-McGuinness C, Hibbert SA, Revote J, Li F, Griffiths CEM, Watson REB, Song J, et al.

(14) Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin HeteromerInternational journal of molecular sciencesJune 12, 2020Dawadi R, Malla N, Hegge B, Wushur I, Berg E, Svineng G, Sylte I, Winberg JO.end (HPX domain) ab38906 was from Abcam (Cambridge, UK). The chromogenic substrate McaPLGLDpaAR-NH2 (ES001) was from R&D Systems, Inc (Minneapolis, MN, USA). 3.2. Biosynthesis of proMMP-9 and CSPGs The human

(15) ELISA assay employing epitope-specific monoclonal antibodies to quantify circulating HER2 with potential application in monitoring cancer patients undergoing therapy with trastuzumabScientific reportsFebruary 20, 2020Agnolon V, Contato A, Meneghello A, Tagliabue E, Toffoli G, Gion M, Polo F, Fabricio ASC.mL−1, code 401353) and 3,3′,5,5′-Tetramethylbenzidine (TMB) liquid substrate system for ELISA (code ES001) were purchased from Merck Millipore and stored at 4 °C together with lyophilized human serum albumin

(16) Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitorsBioorganic chemistryJanuary 1, 2020Bertran A, Khomiak D, Konopka A, Rejmak E, Bulska E, Seco J, Kaczmarek L, Tarragó T, Prades R.

(17) Mitochondrial function in liver cells is resistant to perturbations in NAD⁺ salvage capacityThe Journal of biological chemistrySeptember 6, 2019Dall M, Trammell SAJ, Asping M, Hassing AS, Agerholm M, Vienberg SG, Gillum MP, Larsen S, Treebak JT.

(18) Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetaseThe Journal of biological chemistryAugust 30, 2019Jobin PG, Solis N, Machado Y, Bell PA, Kwon NH, Kim S, Overall CM, Butler GS.

(19) MMP-12, Secreted by Pro-Inflammatory Macrophages, Targets Endoglin in Human Macrophages and Endothelial CellsInternational journal of molecular sciencesJune 25, 2019Aristorena M, Gallardo-Vara E, Vicen M, de Las Casas-Engel M, Ojeda-Fernandez L, Nieto C, Blanco FJ, Valbuena-Diez AC, Botella LM, Nachtigal P, et al.

(20) Habu coagulotoxicity: Clinical implications of the functional diversification of Protobothrops snake venoms upon blood clotting factorsToxicology in VitroMarch 1, 2019Jordan Debono, Mettine H.A. Bos, Amanda Nouwens, Lilin Ge, Nathaniel Frank, Hang Fai Kwok, Bryan G. Fryenzyme buffer, 150 mM NaCl, and 50 mM Tri-HCl (pH 7.3), Fluorogenic Peptide Substrate, R & D systems, Cat#ES001, ES003, ES005, ES010, ES011, Minneapolis, Minnesota). Fluorescence was monitored by a Fluoroskan Ascent™

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Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

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Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate from R&D Systems, a Bio-Techne Brand

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