Description
A metabolite of PGD2 and an agonist of DP2; binds DP2 (Ki = 50 nM) and induces activation of eosinophils (EC50 = 8 nM); induces PPARγ-mediated transcription in a reporter assay at 5 µM; cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml); inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2