Description
A PGE1 analog and agonist of EP2 and EP3 receptors; binds to EP1, EP2, EP3-III, and EP4 receptors (Kis = 35.675, 10.249, 0.319, 5.499 µM, respectively), and is selective for EP receptors over DP, FP, IP, and TP receptors (Kis = >100 µM for all); inhibits electrically induced twitch contraction in isolated guinea pig ileum circular muscle and vas deferens (EC50s = 102.92 and 4.3 nM, respectively), which endogenously express high levels of EP2 and EP3 receptors, respectively; inhibits FMLP-induced superoxide anion generation in human neutrophils (EC50 = 0.35 µM); inhibits ethanol-induced gastric lesion formation in rats (ED50 = 0.31 µg/kg)