U-46619 16450 from Cayman Chemical

Product Specs
ItemU-46619
CompanyCayman Chemical
Price $491.00Supplier Page View Company Product Page
Catalog Number16450
Size5 mg
Research AreaBlood, Cardiovascular System, Coagulation & Hemostasis, Cyclooxygenase Pathway, Lipid Biochemistry, Smooth Muscle Cells, Vasculature
FormatA 10 mg/ml solution in methyl acetate
Molecular Weight350.5
Purity≥98%
Storage-20
FormulaC21H34O4
OriginUSA

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cellsLife Sci AllianceMarch 17, 2026Kévin Leguay, Omaima Naffati, Camila Lie Kiyan, Yu Yan He, Mireille Hogue, Chloé Tesnière, Melania Gombos, Hellen Kuasne, Louis Gaboury, Christian Le Gouill, et al.purchased from NanoLight Technology (#340). U46619 and SQ-29548 were purchased from Cayman Chemical (#16450 and #19025, respectively). Calyculin A and Y-27632 ROCK inhibitors were purchased from Sigma-Aldrich

(2) Re-evaluating Gα protein–response element specificity in GPCR signalingCommunications BiologyJanuary 23, 2026Ayaki Saito, Ryoji Kise, So Yamaguchi, Masataka Yanagawa, Asuka Inouepurchased from Peptide Institute. CL316,243 dihydrochloride (1499) was purchased from Tocris. U-46619 (16450) was purchased from Cayman Chemical. Histamine Dihydrochloride (087-03553) was purchased from FUJIFILM

(3) Endothelial FUNDC1 regulates metabolic reprogramming and the obesity-diabetes transition through the SIRT3/GATA2/endothelin-1 axisNature CommunicationsJanuary 16, 2026Jian Li, Dayong Li, Fujie Zhao, Yadong Wang, Hongmin Yao, Yin Wu, Junqing An, Zhixue Liu, Ye Ding, Ming-Hui Zoudescribed previously63. Mouse descending aortic rings were pre-contracted with 30 nM U46619 (Cayman, 16450). At the plateau of contraction, endothelium-dependent responses were determined in the presence of

(4) Membrane disruption attenuates agonist potency in prostanoid receptorsBiochemical JournalOctober 17, 2025Uurtuya Hochban, Imke Wallenstein, Michaela Ulrich, Alwina Bittner, Lisa Spänig, Katharina Klingelhöfer, Sebastian Neumann, Torsten Steinmetzer, Moritz Bünemann, Michael Kurzmurine α2A-AR conformation sensor CAM [19]. In this study, we used PGE2 (14010), PGD2 (12010), U-46619 (16450), L-161,982 (10011565), Iloprost (18215), and 11-deoxy PGE2 (14520) (all from Cayman Chemical, Ann Arbor,

(5) Kinetics of thromboxane A2 receptor-driven vascular tone in the cerebral cortex ex vivoMicrovascular ResearchSeptember 1, 2025Simone Woodruff, Benjamin Zimmerman, Kevin J. Elk, Jennifer E. Jenks, Danica Bojovic, Anusha Mishraas previously described7, 8. 3 Pharmacology The vasoconstrictor U46619 (Cayman Chemical Company, #16450) was used. Stock solution of U46619 was prepared in dimethyl sulfoxide (DMSO) at 10 mM, stored at −80°C,

(6) Chromatin interaction maps of human arterioles reveal mechanisms for the genetic regulation of blood pressureNat CommunJuly 17, 2025Yong Liu, Rajan Pandey, Qiongzi Qiu, Pengyuan Liu, Hong Xue, Jingli Wang, Bhavika Therani, Rong Ying, Kristie Usa, Michael Grzybowski, et al.system for 30 min and followed by 60 mmHg for another 30 min. After equilibration, U46619 (Catalog No. 16450, Cayman Chemical) was used to pre-constrict the arteriole to 50% to 70% of maximum diameter, followed

(7) Orphan receptor GPR153 facilitates vascular damage responses by modulating cAMP levels, YAP/TAZ signaling, and NF-κB activationNat CommunJuly 7, 2025Jingchen Shao, Jeonghyeon Kwon, Tianpeng Wang, Stefan Günther, Lukas S. Tombor, Timothy Warwick, Zaib Shaheryar, Ralf P. Brandes, Stefanie Dimmeler, Jan Wenzel, et al.contraction; responses to contractile stimuli phenylephrine (10 µM, Sigma, P6126) and U46619 (Cayman, 16450) were normalized to reference contractions elicited by 60 mM K+ Krebs solution. Viability assay To

(8) Physiological role and mechanisms of action for a long noncoding haplotype regionCell ReportsJune 24, 2025Hong Xue, Manoj K. Mishra, Yong Liu, Pengyuan Liu, Michael Grzybowski, Rajan Pandey, Kristie Usa, Mark A. Vanden Avond, Niharika Bala, Abdel A. Alli, et al.system for 30 min and followed by 60 mmHg for another 30 min. After equilibration, U46619 (Catalog No. 16450, Cayman Chemical) was used to pre-constrict the arteriole to 50%–70% of maximum diameter, followed by

(9) 1,8-Cineole inhibits platelet-leukocyte aggregate formation by reducing P-selectin expressionFront PharmacolJune 5, 2025Julie Petry, Han Mai, Maria Shoykhet, Ali Bashiri Dezfouli, Barbara Wollenbergthrombin receptor activator peptide 6 (TRAP, #3497) from Tocris, convulxin (CVX, #119-02) from Pentapharm, U46619 (#16450) from Cayman Chemical, IV.3 was a kind gift from Ronald Taylor (University of Virginia) and goat-anti

(10) Functional characterization of eicosanoid signaling in Drosophila developmentPLoS GenetMay 9, 2025Daiki Fujinaga, Cebrina Nolan, Naoki Yamanakaprostaglandin or a prostanoid analog (Cayman Chemical, PGD2, #12010; PGE2, #14010; PGF2α, #16010; U-46619, #16450; iloprost, #18215). Luminescence was detected every 0.2 seconds from 5 seconds before injection until

(11) Sex differences in middle cerebral artery reactivity and hemodynamics independent from changes in systemic arterial stiffness in Sprague-Dawley ratsPhysiol RepApril 1, 2025Jonathan W. Ray, Xuming Sun, Nildris Cruz-Diaz, Victor M. Pulgar, Liliya M. Yamaleyevastimulated with a sub‐maximal dose of U‐46619 (10−6.5 M, Cayman Chemical, Ann Arbor, MI, USA; Cat #: 16450), once the contraction was stable a dose response curve to acetylcholine (10−10–10−4 M; Cayman Chemical,

(12) Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regenerationImmunityFebruary 11, 2025Connor Lantz, Amanda Becker, Matthew DeBerge, Mallory Filipp, Kristofor Glinton, Aparnaa Ananthakrishnan, Jessica Urbanczyk, Madeline Cetlin, Afnan Alzamroon, Ahmed Abdel-Latif, et al.recombinant proteins","Chemicals, peptides, and recombinant proteins" U-46619,Cayman Chemicals,Cat #: 16450 "SQ29,548",Cayman Chemicals,Cat #: 19025 S18886,Cayman Chemicals,Cat #: 14059 Picotamide,Cayman Chemicals,Cat

(13) Functional characterization of eicosanoid signaling in Drosophila developmentbioRxivJanuary 13, 2025Daiki Fujinaga, Cebrina Nolan, Naoki Yamanakaprostaglandin or a prostanoid analog (Cayman Chemical, PGD2, #12010; PGE2, #14010; PGF2α, #16010; U-46619, #16450; iloprost, #18215). Luminescence was detected every 0.2 seconds from 5 seconds before injection until

(14) Intrauterine Growth Restriction Alters Postnatal Hippocampal Dentate Gyrus Neuron and Microglia Morphology and Cytokine/Chemokine Milieu in MiceLife (Basel)December 9, 2024Frank A. Strnad, Ashley S. Brown, Matthew Wieben, Emilio Cortes-Sanchez, Megan E. Williams, Camille M. Fungeither vehicle (0.5% ethanol = sham or appropriately grown group) or a thromboxane A2-analog, U-46619 (#16450, Cayman Chemical Company, Ann Arbor, MI, USA, MI = IUGR group) dissolved in the vehicle was inserted

(15) Vascular smooth muscle cell PRDM16 regulates circadian variation in blood pressureJournal of Clinical InvestigationDecember 3, 2024Zhenguo Wang, Wenjuan Mu, Juan Zhong, Ruiyan Xu, Yaozhong Liu, Guizhen Zhao, Yanhong Guo, Jifeng Zhang, Ida Surakka, Y. Eugene Chen, et al.water), PGF2α (catalog P5069, MilliporeSigma, stock solution 10 μM in ethanol), and U-46619 (catalog 16450, Cayman Chemical) were assessed to characterize vasoconstriction. To characterize vasodilation, the

(16) Knockout of Sirtuin 3 in endothelial cells impairs endothelial‐dependent relaxation and myogenic response in micePhysiological ReportsOctober 19, 2024Jian‐Xiong Chen, Jin Zhang, Yingjie Chen, Heng Zeng10−9–10−5 M. U‐46619 (a selective agonist of prostaglandin H2/thromboxane A2 receptor, catalogue number:16450, Cayman Chemical Company) was used to induce vasoconstriction before testing EDR and EIR (Sabe et al.,

(17) A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disordersNat Cardiovasc ResFebruary 1, 2024Gandhi PS, Zivkovic M, Østergaard H, Bonde AC, Elm T, Løvgreen MN, Schluckebier G, Johansson E, Olsen OH, Olsen EHN, et al.µM adenosine diphosphate (ADP) (Sigma, 01897), 1 µg ml−1 CRP-XL and 5 µM U-46619 (Cayman Chemical, 16450). This was incubated for 10 min at 37 °C in the dark to allow platelet activation. Platelet activation

(18) Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory DiseaseThe Journal of ImmunologyDecember 15, 2023Dinah Foer, Taneem Amin, Jun Nagai, Yumi Tani, Chunli Feng, Tao Liu, Dawn C. Newcomb, Juying Lai, Hiroaki Hayashi, William E. Snyder, et al.SQ 29,548 (Cayman Chemical #19025)(27, 28). Thromboxane (TXA2) analogue U46619 was from Cayman Chemical (#16450). Use of the reagent is discussed in further detail in the Human Studies section of these methods. GLP-1

(19) Inhibition of TP signaling promotes endometriosis growth and neovascularizationMolecular medicine reportsOctober 1, 2023Furue A, Hattori K, Hosono K, Tanabe M, Sato E, Honda M, Sekiguchi K, Ito Y, Majima M, Narumiya S, et al.described (9). On day 7, the cells stimulated with the TP receptor agonist U46619 (100 nM; catalog no. 16450; Cayman Chemical) were either left untreated or treated with lipopolysaccharide (10 ng/ml; cat. no.

(20) p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscleFrontiers in PhysiologySeptember 13, 2023Jaspreet Kalra, Mykhaylo Artamonov, Hua Wang, Aaron Franke, Zaneta Markowska, Li Jin, Zygmunt S. Derewenda, Ramon J. Ayon, Avril SomlyoSigma-Aldrich, St. Louis Mo. United States; U46619 stock solution 5 mg in 500 μL methyl acetate, catalog no 16450, Cayman Chemicals, Ann Arbor, Mi, United States; LJH685 stock solution 10 mM in DMSO, catalog no. 19913,

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U-46619 from Cayman Chemical

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U-46619 from Cayman Chemical

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