Description
A PGF2α analog and prodrug form of (+)-fluprostenol; an FP receptor agonist (EC50 = 40.2 nM for induction of phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor); topical application induces miosis in conscious cats in a dose-dependent manner at 0.01, 0.03, and 0.1 µg; reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension when administered topically at 0.1 and 0.3 µg twice per day