16,16-dimethyl Prostaglandin E2 14750 from Cayman Chemical

Product Specs
Item16,16-dimethyl Prostaglandin E2
CompanyCayman Chemical
Price $570.00Supplier Page View Company Product Page
Catalog Number14750
Size5 mg
FormatA 10 mg/ml solution in methyl acetate
Research AreaCell Biology, Cyclooxygenase Pathway, Differentiation, Endocrinology & Metabolism, Lipid Biochemistry, Proliferation, Reproductive Biology, Stem Cell Research
Molecular Weight380.5
Purity≥95%
Storage-20
FormulaC22H36O5
OriginUSA

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) The COX2-PGE2-PKA Axis Suppresses Antiviral Immunity by Inhibiting mtDNA-Dependent STING ActivationbioRxivApril 6, 2026Pham Thuy Tien Vo, Julien Cicero, Zichen Wang, Hiroyuki Hakozaki, Thomas S Hoang, Sendi Rafael Adame-Garcia, Dana J. Ramms, Kuniaki Sato, Erica Stevenson, Yuan Zhou, et al.cells/well) and serum-starved for 12 hours. Cells were then stimulated with 16,16-dimethyl-PGE2 (Cayman, 14750), forskolin (Sigma, F6886), IBMX (Sigma, I5879). For inhibition studies, cells were pre-incubated with

(2) Dynamic Reprogramming of PDGFRA-Expressing Stromal Cells Facilitates WNT-Driven Transformation by Promoting a Fetal-Like State in the Intestinal EpitheliumCancer ResMarch 5, 2026Oscar Pellon-Cardenas, Prateeksha Rout, Sohaib Hassan, Emily Fokas, Isha Patel, Jay Patel, Xia Qiu, Ping He, Olivia Nussbaum, Alex Wu, et al.BMP2 (R&D 355-BM) at a final concentration of 100 – 400 ng/mL, (16,16-dimethyl PGE2 (Cayman, Cat no. 14750) dissolved in ethanol at a final concentration of 10 μM, EREG (R&D Systems, Cat. no. 1068-EP-050) dissolved

(3) Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesisCell Chem BiolFebruary 19, 2026Peter Geon Kim, Christopher B Hergott, Aidan P Miller, Amy Deik, Meaghan Boileau, Kevin Bullock, Kerry A. Pierce, Angelina H. Choy, Wesley Shin, Marie McConkey, et al.treatments, the following drugs were used OSMI1 (Cayman Chemical 21894), 16,16-dimethylPGE2 (Cayman Chemical 14750), (Z)-PUGNAc (Cayman Chemical 17151), doxycycline (Selleck Chemicals S4163), biotin (Sigma B4501–5G),

(4) Genome-wide CRISPR Screening Reveals a PKA-Driven Resistance Mechanism to Metformin for Oral Cancer Prevention That Can Be Exploited by Combination with NSAIDsCancer Prevention ResearchFebruary 6, 2026Thomas S. Hoang, Farhoud Faraji, Amaya N. Mendez-Molina, Sendi Rafael Adame-Garcia, Kuniaki Sato, Tomohiko Ishikawa, Pham Thuy Tien Vo, Sydney I. Ramirez, Paola Y. Anguiano Anguiano Quiroz, Tracy Guo, et al.Chemical. Forskolin (cat. #1099) was purchased from Tocris. 16,16-dimethyl Prostaglandin E2 (cat. #14750) was purchased from Cayman Chemical. BLU0588 (cat. #HY-153967) was purchased from MedChemExpress. Celecoxib

(5) Genome-wide CRISPR screening reveals a PKA-driven resistance mechanism to metformin for oral cancer prevention that can be exploited by combination with NSAIDsCancer Prev Res (Phila)February 6, 2026Thomas S. Hoang, Farhoud Faraji, Amaya N. Mendez-Molina, Sendi Rafael Adame-Garcia, Kuniaki Sato, Tomohiko Ishikawa, Pham Thuy Tien Vo, Sydney I. Ramirez, Paola Y. Anguiano Quiroz, Tracy Guo, et al.Chemical. Forskolin (cat. #1099) was purchased from Tocris. 16,16-dimethyl Prostaglandin E2 (cat. #14750) was purchased from Cayman Chemical. BLU0588 (cat. #HY-153967) was purchased from MedChemExpress. Celecoxib

(6) Nanoengineered 3D culture substrate enables superior persistence and polyclonal engraftment of genetically engineered hematopoietic stem cellsCell Stem CellFebruary 5, 2026Federico Midena, Laura Alessandrini, Claudio Conci, Matteo Barcella, Francesco Gazzo, Emanuela Jacchetti, Edoardo Carsana, Fabrizio Benedicenti, Roberta Vacca, Lucrezia della Volpe, et al.proteins","Chemicals, peptides, and recombinant proteins" ,, "16,16-Dimethyl Prostaglandin E2",Cayman Chemical,Cat#14750 7-AAD Viability Staining solution,Biolegend,Cat#420403 ABE8.20-m,Fiumara et al.,N/A Alt-R CRISPR-Cas9

(7) Protein kinase a regulates cyclooxygenase-2 expression through the RNA-binding proteins HuR and TTPJournal of Biological ChemistryFebruary 1, 2026Sendi Rafael Adame-Garcia, Thomas S. Hoang, Pham Thuy Thien Vo, Valeria Burghi, Rodolfo Daniel Cervantes-Villagrana, Lennis Beatriz Orduña-Castillo, Dana J. Ramms, JoAnn Trejo, J. Silvio Gutkindcells/well) and serum-starved for 12 h. Cells were then stimulated with 16,16-dimethyl-PGE2 (Cayman, 14750), forskolin (Sigma-Aldrich, F6886), IBMX (Sigma-Aldrich, I5879), or recombinant human or mouse IL-1β

(8) Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cellsCell Rep MedJune 17, 2025Anastasia Conti, Kety Giannetti, Federico Midena, Stefano Beretta, Nicolò Gualandi, Rosaria De Marco, Edoardo Carsana, Angelica Varesi, Teresa Tavella, Laura Alessandrini, et al.proteins","Chemicals, peptides, and recombinant proteins" ,, "16,16-Dimethyl Prostaglandin E2",Cayman Chemical,Cat#14750 Recombinant human stem cell factor (SCF),Peprotech,Cat#300-07 Recombinant human thrombopoietin (TPO),Peprotech,Cat#300-18 Recombinant human Flt3-Ligand

(9) Protocol for optimizing culture conditions for ex vivo activation during CRISPR-Cas9 gene editing in human hematopoietic stem and progenitor cellsSTAR ProtocMarch 31, 2025Lucrezia Della Volpe, Roberta Vacca, Raffaella Di Miccoproteins","Chemicals, peptides, and recombinant proteins" ,, "16,16-dimethyl prostaglandin E2",Cayman Chemical,Cat#14750 StemSpan SFEM,STEMCELL Technologies,Cat#09650 MethoCult,STEMCELL Technologies,Cat#H4434 "Iscove’s

(10) Schwann cell-secreted PGE2 promotes sensory neuron excitability during developmentCellAugust 22, 2024Husniye Kantarci, Pablo D. Elvira, Arun P. Thottumkara, Emma M. O’Connell, Manasi Iyer, Lauren J. Donovan, Micaela Quinn Dugan, Nicholas Ambiel, Alejandro Granados, Hong Zeng, et al.water (2–3 °C) in a latex glove/sleeve. 2 μL of injection solution (~7.61 ng/μL [20 μM] dmPGE2 (Cayman, 14750) or 0.2% ethanol vehicle control in half PBS and half Trypan Blue [0.4%, ThermoFisher Scientific, 15250061])

(11) Mast cells control lung type 2 inflammation via prostaglandin E2-driven soluble ST2ImmunityJune 1, 2024Kinan Alhallak, Jun Nagai, Kendall Zaleski, Sofia Marshall, Tamara Salloum, Tahereh Derakhshan, Hiroaki Hayashi, Chunli Feng, Radomir Kratchmarov, Juying Lai, et al.Sigma,D4876 Gentamicin,Thermofisher Scientific,15710064 "16,16-dimethyl prostaglandin E2",Cayman Chemical,14750 ONO-8130 EP1 antagonist,Cayman Chemical,19118 PF-04418948 EP2 antagonist,Cayman Chemical,15016 "L-798,106

(12) Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentationNature communicationsJanuary 27, 2024An L, Kim D, Donahue LR, Mejooli MA, Eom CY, Nishimura N, White AC.second UVB irradiation, as previously described41. Prostaglandin treatment 10 µg of dmPGE2 (Cayman Cat#14750) was dissolved in 50 µl PBS with 10% EtOH, and intradermally injected daily under UVB-irradiated skin. Diphtheria

(13) A moderate dosage of Prostaglandin E2-mediated Annexin A1 upregulation promotes alkali-burned corneal repairiScienceDecember 15, 2023Hongling Liu, Xue Zhang, Qiang Tan, Lingling Ge, Jia Lu, Chunge Ren, Baishijiao Bian, Yijian Li, Yong Liupeptides, and recombinant proteins" ,, PGE2,Cayman Chemical,Cat#14010 dmPGE2,Cayman Chemical,Cat#14750 CAY10526,Cayman Chemical,Cat#10010088 Ac2-26,Tocris Bioscience,Cat#1845 NaOH,Sangon biotech,Cat#A620617 Phosphate

(14) A neomorphic mutation in the interferon activation domain of IRF4 causes a dominant primary immunodeficiencyThe Journal of experimental medicineJune 5, 2023Thouenon R, Chentout L, Moreno-Corona N, Poggi L, Lombardi EP, Hoareau B, Schmitt Y, Lagresle-Peyrou C, Bustamante J, André I, et al.After 24 h, the cells were transduced using adjuvant (Lentiboost, Sirion Biotech, and PGE2 Cayman, #14750) and lentiviral vectors (pWPI backbone) expressing WT or mutant IRF4. For T cell polarization 1 d after

(15) Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentationbioRxiv : the preprint server for biologyMay 22, 2023An L, Kim D, Donahue L, Mejooli MA, Chi-Yong E, Nishimura N, White AC.second UVB irradiation, as previously described41. Prostaglandin treatment: 10ug of dmPGE2 (Cayman Cat#14750) was dissolved in 50ul PBS with 10% EtOH, and intradermally injected daily under UVB irradiated skin. Ruxolitinib

(16) PGE 2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fateProceedings of the National Academy of SciencesMay 9, 2023Audrey Sporrij, Avik Choudhuri, Meera Prasad, Brejnev Muhire, Eva M. Fast, Margot E. Manning, Jodi D. Weiss, Michelle Koh, Song Yang, Robert E. Kingston, et al.CO2. dmPGE2 Treatment. 16,16-dimethyl PGE2 was purchased, reconstituted in DMSO from Cayman Chemicals (cat. #14750), aliquoted, and stored in −80 °C until use. Cells were counted, collected, and resuspended in StemSpan

(17) Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cellsCell stem cellOctober 6, 2022Ferrari S, Jacob A, Cesana D, Laugel M, Beretta S, Varesi A, Unali G, Conti A, Canarutto D, Albano L, et al.proteins","Chemicals, peptides, and recombinant proteins" ,, "16,16-dymethylprostaglandin E2",Cayman Cat,Cat# 14750 StemSpan SFEM,VODEN,Cat# 09650 Recombinant human stem cell factor,Peprotech,Cat# 300-07 Recombinant

(18) External signals regulate continuous transcriptional states in hematopoietic stem cellseLifeDecember 23, 2021Fast EM, Sporrij A, Manning M, Rocha EL, Yang S, Zhou Y, Guo J, Baryawno N, Barkas N, Scadden D, et al.,Miltenyi Biotech,130-090-858, "Chemical compound, drug",Poly(I:C) HMW,Invivogen,tlrl-pic-5, "Chemical compound, drug",DmPGE2,Cayman,14750, "Chemical compound, drug",G-CSF,Thermo Fisher,PHC2031, "Chemical compound, drug",Indomethacin,Sigma,PHR1247-500MG, "Software,

(19) A role for glial fibrillary acidic protein (GFAP)-expressing cells in the regulation of gonadotropin-releasing hormone (GnRH) but not arcuate kisspeptin neuron output in male miceeLifeJuly 22, 2021Vanacker C, Defazio RA, Sykes CM, Moenter SM.neuron firing, we used 16,16-dimethyl PGE2 (dmPGE2, 200 nM), a stable form of PGE2 (Cayman Chemical 14750) in 0.00076% methyl acetate vehicle. Antagonists for prostaglandin receptor EP1 (SC-19220, 100 μM, Tocris)

(20) Paracrine orchestration of intestinal tumorigenesis by a mesenchymal nicheNatureApril 1, 2020Roulis M, Kaklamanos A, Schernthanner M, Bielecki P, Zhao J, Kaffe E, Frommelt LS, Qu R, Knapp MS, Henriques A, et al.(Stem Cell Technologies, 06010) according to the manufacturer’s guidelines. When indicated, 16,16-dimethyl PGE2 (Cayman, 14750) dissolved in ethanol was added daily at a final concentration of 0.1 μM. Ethanol was used as a vehicle

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16,16-dimethyl Prostaglandin E2 from Cayman Chemical

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Cayman Chemical

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16,16-dimethyl Prostaglandin E2 from Cayman Chemical

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