Description
A DP receptor antagonist (Ki = ~1.7 nM); selective for the DP receptor over human TP, IP, EP1, EP2, and FP receptors; antagonizes PGD2- and BW 245C-induced activation of human platelet adenylate cyclase; reverses the anti-aggregatory effects of DP receptor agonists; antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells