Human BMP-2 Recombinant Protein 4697S from Cell Signaling Technology

Product Specs
ItemHuman BMP-2 Recombinant Protein
CompanyCell Signaling Technology
Price $315.00 Inquire
Catalog Number4697S
Size10 µg
Molecule NameBMP2
NCBI Gene AliasesBDA2, BMP2A, SSFSC, SSFSC1
NCBI Full Gene Namebone morphogenetic protein 2
Research AreaDevelopmental Biology
Molecular Weight26
Source/Expression SystemE. Coli
ApplicationsW

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) α-Parvin promotes glucose uptake and metabolism in skeletal muscle with minimal influence on hepatic insulin sensitivityMolecular MetabolismMarch 1, 2026Fabian Bock, Xinyu Dong, Kakali Ghoshal, David A. Cappel, John W. Deaver, Dan S. Lark, Luciano Cozzani, Deanna P. Bracy, Louise Lantier, Allison Do, et al.subjected to SDS-PAGE, and actin was detected by Western blot using a rabbit anti–β-actin antibody (CST, #4697). 2.12 Rho GTPase activity, Rac1 activity, and Peroxidase Activity Assays Activation of Rho GTPases

(2) Phospho-Proteomic Analysis of Interleukin-13 Signaling in Airway Cells Reveals SRC Family Kinase Involvement in Interleukin-13-Induced Inflammatory ResponsesInternational Archives of Allergy and ImmunologyNovember 10, 2025Archana Shankar, Jaclyn W. McAlees, Michael A. Wyder, Julie M. Hargis, Harshavardhana Haresamudram Ediga, Angela Cannata, Jana Latayan, Kenneth D. Greis, Satish K. Madala, Ian P. Lewkowich#9362), total SRC (Cell Signaling Technology, #2108S), and either β-actin (Cell Signaling Technology, #4697S) or GAPDH (Cell Signaling Technology, #2118S), according to the manufacturer’s protocols. Phospho-SRC

(3) Response Gene to Complement 32 promotes cell proliferation and tamoxifen resistance in breast cancer via elevated FoxM1 expressionPLoS OneJuly 28, 2025Xinlei Li, Yan Liu, Zhiqian Wang, Xiaocui Bu, Yu Wang, Wei Zhang, Peng Zhaoand Ser35 (Invitrogen, PA5–105625, PA5–105197), Cdk1 (Abcam, ab265590), total-AKT (Cell signaling, 4697) and p-AKT (Cell signaling, 4060). HRP-conjugated anti-rabbit were used as secondary antibodies. The

(4) Targeting the dual miRNA/BMP2 network: LncRNA H19-mediated temozolomide resistance unveils novel therapeutic strategies in glioblastomaFront OncolApril 14, 2025Qiudan Chen, Shihao Zhuang, Shuying Chen, Biying Wu, Qingyu Zhou, Weifeng WangMillipore, Billerica, USA). Primary antibodies, including α-tubulin (Cell Signaling Technology, Cat#4697S) and BMP2 (Merck, Cat. No. ABN898), were used at a dilution of 1:1000. Protein bands were detected using

(5) Sodium butyrate restored TRESK current controlling neuronal hyperexcitability in a mouse model of oxaliplatin-induced peripheral neuropathic painNeurotherapeuticsJanuary 1, 2025Idy H.T. Ho, Yidan Zou, Kele Luo, Fenfen Qin, Yanjun Jiang, Qian Li, Tingting Jin, Xinyi Zhang, Huarong Chen, Likai Tan, et al.(#YK006, Immunoway, Plano, TX, USA), AcH3K14 (#07–353, Merck Millipore, Burlington, MA, USA), b-actin (#4697, Cell Signaling technology, Danvers, MA, USA) or Tubulin (#2146S, Cell Signaling technology, Danvers,

(6) Comparison of the protective effects of chitosan oligosaccharides and chitin oligosaccharide on apoptosis, inflammation and oxidative stressExperimental and Therapeutic MedicineJune 5, 2024Qiongyu Li, Wan-Rong Shi, Yun-Lin HuangBcl-2 (cat. no. 4223), Bax (cat. no. 5023), PARP, cleaved-PARP (cat. no. 9542) and β-actin (cat. no. 4697) from Cell Signaling Technology, Inc., at 4˚C overnight. After incubating with horseradish peroxidase-conjugated

(7) Full T-cell activation and function in teleosts require collaboration of first and co-stimulatory signalsZoological ResearchJanuary 18, 2024Wei Liang, 华东师范大学生命科学学院河口海岸国家重点实验室, 上海 200241, 中国, State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, Shanghai 200241, China, Kang Li, Haiyou Gao, Kunming Li, Jiansong Zhang, Qian Zhang, Xinying Jiao, Jialong Yang, et al.(#2250), anti-PI3 Kinase p110α (#4249), anti-p-AKT (Thr308,#13038), anti-p-AKT (Thr473, #4060), anti-AKT (#4697), anti-p-S6 (Ser240/244, #5364), anti-S6 (#2217), anti-p-4EBP1 (Thr37/46, #5123), anti-4EBP1 (#9959),

(8) Application of Condition Monitoring for Hydraulic Oil Using Tuning Fork Sensor: A Study Case on Hydraulic System of Earth Moving MachineryMaterials (Basel)October 31, 2022Hong-Gyu Jeon, Jong-Kyun Kim, Seon-Jun Na, Min-Seok Kim, Sung-Ho HongSampling(May 2022),3rd Oil Sampling(August 2022) Monitoring A,4495 h,4967 h,5591 h,5848 h Monitoring B,4697 h,5191 h,5808 h,6380 h Monitoring C,5450 h,6040 h,6700 h,7163 h Monitoring D,2109 h,2974 h,3858 h,4641

(9) Deletion of Mechanosensory β1-integrin From Bladder Smooth Muscle Results in Voiding Dysfunction and Tissue RemodelingFunction (Oxf)September 13, 2022Weiqun Yu, Bryce MacIver, Lanlan Zhang, Erica M Bien, Nazaakat Ahmed, Huan Chen, Sarah Z Hanif, Mariana G de Oliveira, Mark L Zeidel, Warren G Hillab126168) were from Abcam (Waltham, MA, USA); α1-integrin (#71 747), β3-integrin (#13 166), and β-actin (#4697) were from Cell Signaling Technology (Danvers, MA, USA); M2 (G206) was from Assay Biotech (Fremont,

(10) Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against EosinophiliaMolecules (Basel, Switzerland)August 25, 2022Shaha A, Islam R, Tanaka N, Kashiwada Y, Fukui H, Takeda N, Kitamura Y, Mizuguchi H.(E-4, sc-7383) were from Santa Cruz Biotechnology (Santa Cruz, CA, USA). The antibody for β-actin (#4697) was from Cell Signaling Technology Japan (Tokyo, Japan). Goat anti-rabbit IgG (H+L)-HRP conjugate (#170-6515)

(11) Senescence Induced by BMI1 Inhibition is a Therapeutic Vulnerability in H3K27M-Mutant DIPGSSRN Electronic JournalApril 2, 2022Ilango Balakrishnan et al.abundance of GFAPpositive cells that is mediated by PTGDS in mouse brain. Hum. Mol. Genet. 24, 4686–4697. Cell Reports 33, 108286, October 20, 2020 19 ll OPEN ACCESS Article STAR+METHODS KEY RESOURCES

(12) Doublecortin in the Fish Visual System, a Specific Protein of Maturing NeuronsBiologyFebruary 6, 2022DeOliveira-Mello L, Vicente I, Gonzalez-Nunez V, Santos-Ledo A, Velasco A, Arévalo R, Lara JM, Mack AF.SDS, and TBS-T. β-actin antibody (1:1.000 diluted in blocking buffer; Cell Signalling, Danvers, USA, 4697. Lot nº. 10/2016) was used as loading control. Protein expression was determined by densitometric analysis

(13) Osteoblastic glucocorticoid signaling exacerbates high-fat-diet- induced bone loss and obesityBone researchSeptember 1, 2021Kim S, Henneicke H, Cavanagh LL, Macfarlane E, Thai LJ, Foong D, Gasparini SJ, Fong-Yee C, Swarbrick MM, Seibel MJ, et al.against sclerostin (0.2 μg·mL−1, #AF1589, R&D Systems, Minneapolis, MN, U.S.A.) or beta-actin (1:1 000, #4697, Cell Signaling Technology, Danvers, MA, U.S.A.). After incubation with appropriate secondary antibodies,

(14) SphK1 functions downstream of IGF-1 to modulate IGF-1-induced EMT, migration and paclitaxel resistance of A549 cells: A preliminary in vitro studyJournal of CancerJuly 10, 2019Xingping Wu, Qibiao Wu, Xiqiao Zhou, Jianan Huang92547), anti-p-ERK1/2 (Cell Signaling Technology Cat# 4377), anti-ERK (Cell Signaling Technology Cat# 4697), anti-p-AKT(S473) (Cell Signaling Technology Cat# 9271 ), anti-AKT (Abcam Cat# AB8805), anti-GAPDH

(15) GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updatingScientific reportsMarch 26, 2019Ferrara NC, Jarome TJ, Cullen PK, Orsi SA, Kwapis JL, Trask S, Pullins SE, Helmstetter FJ.CA). Antibodies Western blot antibodies included GluR2 (1:1000, NeuroMab #75-002) and Actin (Cell Signaling, 1:1000 #4697) as a loading control. Immunofluorescence antibodies included zif268 (Cell Signaling, 1:500) and Anti-Ubiquitin

(16) ARHGEF4 predicts poor prognosis and promotes cell invasion by influencing ERK1/2 and GSK-3α/β signaling in pancreatic cancerInternational journal of oncologyNovember 1, 2018Taniuchi K, Furihata M, Naganuma S, Saibara T.anti-GAPDH (sc32233) antibodies were purchased from Santa Cruz Biotechnology, Inc. (Dallas, TX, USA). Anti-ERK1/2 (4697) and anti-phosphorylated ERK1/2 (Thr204/Tyr187; 5726) antibodies were purchased from Cell Signaling Technology

(17) Effect of wild grape on the signaling of histamine H₁ receptor gene expression responsible for the pathogenesis of allergic rhinitisThe Journal of Medical InvestigationOctober 5, 2018Rezwanul Islam, Hiroyuki Mizuguchi, Aurpita Shaha, Kohei Nishida, Masami Yabumoto, Hisashi Ikeda, Hiromichi Fujino, Yoshiaki Kitamura, Hiroyuki Fukui, Noriaki Takeda(sc-937, Santa Cruz Biotechnology, Santa Cruz, CA, USA) and phospho-PKCδ (Tyr311) and β-actin (#2055S and #4697, Cell Signaling Technology Japan, Tokyo)] overnight at 4" !. Proteins were visualized with an Immobilon Western Chemiluminescent HRP substrate

(18) Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signalingeLifeDecember 15, 2017Wang Y, Zhang X, Huang H, Xia Y, Yao Y, Mak AF, Yung PS, Chan KM, Wang L, Zhang C, et al.kit,Dual-luciferase reporter assay system,"Promega, USA",E1980 "Chemical compound, drug",BMP2,"CST, USA",#4697 "Chemical compound, drug",TGF-β1,"Peprotech, USA",100–21 "Chemical compound, drug",Purmorphamine,"Millipore,

(19) The target landscape of clinical kinase drugsScience (New York, N.Y.)December 1, 2017Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, et al.Gilteritinib 1 µM, Saracatinib 1µM, 100 nM, 10 nM in DMSO) for 30 min prior to addition of 100 ng/ml BMP2 (#4697, Cell signaling technology), followed by 45 min incubation before cells were lysed using an NP40-based

(20) Comparison of two different analysis approaches for DTI free-water corrected and uncorrected maps in the study of white matter microstructural integrity in individuals with depressionHuman Brain MappingSeptember 1, 2017Maurizio Bergamino, Rayus Kuplicki, Teresa A. Victor, Yoon-Hee Cha, Martin P. PaulusL. Fewer clusters were found when RD-FW maps were used. Additionally, with RD maps we found higher 4697 r r Bergamino et al. r TABLE III. Pearson’s correlation coefficients between PHQ-9 scores and

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Human BMP-2

Human BMP-2 Recombinant Protein from Cell Signaling Technology

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Human BMP-2 Recombinant Protein from Cell Signaling Technology

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