VEGF 121, aa 207-327 Protein 4644-VS-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemVEGF 121, aa 207-327 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $351.00Supplier Page View Company Product Page
Catalog Number4644-VS-010
SpeciesHuman
Size10 ug
Molecule NameVEGF
NCBI Full Gene Namevascular endothelial growth factor A
NCBI Gene AliasesMVCD1, VPF, VEGF
FormatLyophilized from a 0.2 µm filtered solution in HCl with BSA as a carrier protein
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
Source/Expression SystemE. coli-derived Recombinant Human VEGF 121 (aa 207-327) Protein

Specifications/Features

Available conjugates: Sizes Available: 10 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) VEGF-A isoforms induce the expression of APLN in endothelial cells during human prenatal lung developmentFrontiers in Cell and Developmental BiologyJanuary 23, 2026Antony Hoarau, Andrew Frauenpreis, Randa Belgacemi, Emma Loeffler, Osshaya Maalouf, Ian A. Glass, Denise Al Alam, Soula Danopoulosrefreshed every 24 h over a 48-h culture period. The rhVEGF-A isoforms come from R&D system (VEGF-A121: cat#4644-VS-010, VEGF-A145: cat#7626-VE-010, VEGF-A165: cat#293-VE-010, VEGF-A189: cat#8147-VE-025). Considering the

(2) Developing a dual VEGF/PDL1 inhibitor based on high-affinity scFv heterodimers as an anti-cancer therapeutic strategyScientific reportsJuly 24, 2023Tzuri N, Yegodayev KM, Novoplansky O, Elkabets M, Aharoni A, Papo N.

(3) Syndecan-2 selectively regulates VEGF-induced vascular permeabilityNat Cardiovasc ResMay 1, 2022Corti F, Ristori E, Rivera-Molina F, Toomre D, Zhang J, Mihailovic J, Zhuang ZW, Simons M.

(4) Assessment of mouse VEGF neutralization by ranibizumab and afliberceptPloS oneJanuary 1, 2022Ichiyama Y, Matsumoto R, Obata S, Sawada O, Saishin Y, Kakinoki M, Sawada T, Ohji M.

(5) CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistanceCell reportsAugust 17, 2021Ma S, Mangala LS, Hu W, Bayaktar E, Yokoi A, Hu W, Pradeep S, Lee S, Piehowski PD, Villar-Prados A, et al.Recombinant human VEGF 165 protein,R&D Systems,Cat. #293-VE-010 Recombinant Human VEGF 121 (aa 207-327) Protein,R&D Systems,Cat. #4644-VS-010 Recombinant Human VEGF 189 (aa 27-215) Protein,R&D Systems,Cat. #8147-VE-025 Bevacizumab,Genentech,NDC

(6) Heparin-binding VEGFR1 variants as long-acting VEGF inhibitors for treatment of intraocular neovascular disordersProceedings of the National Academy of SciencesMay 25, 2021Hong Xin, Nilima Biswas, Pin Li, Cuiling Zhong, Tamara C. Chan, Eric Nudleman, Napoleone Ferrarain a 200-μL volume. rhVEGF165 (R&D Systems, Cat. No. 293-VE-010) or rhVEGF121 (R&D Systems, Cat. No. 4644-VS010) was added at a concentration of 10 ng/mL. Aflibercept (Eylea) was purchased from a pharmacy. The inhibitors

(7) VEGF counteracts amyloid-β-induced synaptic dysfunctionCell reportsMay 11, 2021Martin L, Bouvet P, Chounlamountri N, Watrin C, Besançon R, Pinatel D, Meyronet D, Honnorat J, Buisson A, Salin PA, et al.

(8) Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic micePloS oneJanuary 1, 2020Njau F, Shushakova N, Schenk H, Wulfmeyer VC, Bollin R, Menne J, Haller H.

(9) VEGF-A-Cleavage by FSAP and Inhibition of Neo-VascularizationCellsNovember 6, 2019Uslu Ö, Herold J, Kanse SM.

(10) Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting CellsJournal of immunology (Baltimore, Md. : 1950)February 15, 2019Stephenson S, Care MA, Fan I, Zougman A, Westhead DR, Doody GM, Tooze RM.

(11) A VEGF-A/SOX2/SRSF2 network controls VEGFR1 pre-mRNA alternative splicing in lung carcinoma cellsScientific reportsJanuary 23, 2019Abou Faycal C, Gazzeri S, Eymin B.

(12) Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using ¹¹¹In-bevacizumabEJNMMI researchDecember 1, 2017Patel N, Able S, Allen D, Fokas E, Cornelissen B, Gleeson FV, Harris AL, Vallis KA.methane-HCl (Bis-Tris) precast gel (Invitrogen). The following standard proteins were used: VEGF121 (4644-VS-010, R&D Systems), VEGF165 (293-VE-010, R&D Systems) and VEGF189 (ab106307, Abcam). Primary antibodies,

(13) Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesisBioengineering & translational medicineMarch 1, 2017Kapur S, Silverman AP, Ye AZ, Papo N, Jindal D, Blumenkranz MS, Cochran JR.

(14) Fluorescent resonance energy transfer imaging of VEGFR dimerizationAnticancer researchMay 1, 2014Ahmadova Z, Yagublu V, Förg T, Hajiyeva Y, Jesenofsky R, Hafner M, Keese M.

(15) The docking protein FRS2α is a critical regulator of VEGF receptors signalingProceedings of the National Academy of Sciences of the United States of AmericaApril 15, 2014Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M.stimulation), VEGF-A165 (R&D Systems 293-VE-010; for in vitro stimulation), VEGF-A121 (R&D Systems 4644-VS-010; for in vitro stimulation), VEGF-C (R&D Systems 2179-VC-025; for in vitro stimulation), VEGF-C (R&D Systems

(16) Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathwayRespiratory researchMarch 19, 2014Esquibies AE, Karihaloo A, Quaggin SE, Bazzy-Asaad A, Cantley LG.

(17) Mechanism of a flow-gated angiogenesis switch: early signaling events at cell–matrix and cell–cell junctionsIntegrative BiologyJune 8, 2012Vernella Vickerman, Roger D. Kammmedium supplemented with 20 ng/ml VEGF165 (293-VE-010, R&D Systems Inc., Minneapolis, MN) or VEGF121 (4644-VS-010, R&D Systems Inc.). At this concentration, VEGF was not at sufficient level to induce sprouting under

(18) The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domainFASEB journal : official publication of the Federation of American Societies for Experimental BiologyDecember 1, 2010Martino MM, Hubbell JA.

(19) VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivoBritish journal of cancerOctober 6, 2009Rennel ES, Varey AH, Churchill AJ, Wheatley ER, Stewart L, Mather S, Bates DO, Harper SJ.

(20) Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglinPloS oneJanuary 1, 0001"Tannetta DS, Dragovic RA, Gardiner C, Redman CW, Sargent IL."

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VEGF 121, aa 207-327 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (20)

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VEGF 121, aa 207-327 Protein from R&D Systems, a Bio-Techne Brand

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