Recombinant Mouse Klotho (aa 35-982) Protein, CF 1819-KL-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse Klotho (aa 35-982) Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $479.00Supplier Page View Company Product Page
Catalog Number1819-KL-050
SpeciesMouse
FormatSupplied as a 0.2 µm filtered solution in PBS, Glycerol and EDTA
Molecule NameKlotho
Size50 ug
NCBI Full Gene Nameklotho
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 125-130 kDa, reducing conditions
Theoretical: 109.5 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
NCBI Gene Aliasesalpha-kl
Source/Expression SystemCHO-derived Recombinant Mouse Klotho (aa 35-982) Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after opening

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Fibroblast Growth Factor 23 as a Prognostic Biomarker in Post‐Myocardial Infarction Outcomes: Influence of Renal Function and Its Modulation by KlothoJournal of the American Heart AssociationFebruary 17, 2026Sara Vázquez‐Sánchez, Ana Blasco, Marina Polo‐Salguero, Laura Mourino‐Álvarez, Marta Gil‐Fernández, Nerea Corbacho‐Alonso, José Alberto Navarro‐García, Elisa Mercado‐García, Laura González‐Lafuente, Elena Rodríguez‐Sánchez, et al.intraperitoneal injections of either 0.9% sodium chloride (vehicle) or recombinant murine Klotho (10 μg/kg per day) (1819‐KL‐050; R&D Systems, Minneapolis, MN). Sham or post‐MI (PMI) surgery mice were blindly randomized using simple

(2) Recombinant Klotho administration after myocardial infarction reduces ischaemic injury and arrhythmias by blocking intracellular calcium mishandling and CaMKII activationThe Journal of PathologyJanuary 15, 2025Sara Vázquez‐Sánchez, Ana Blasco, Pablo Fernández‐Corredoira, Paula Cantolla, Elisa Mercado‐García, Elena Rodríguez‐Sánchez, Laura González‐Lafuente, Jonay Poveda, Daniel González‐Moreno, Andrea Matutano, et al.Klotho (10 μg/kg/day) dissolved in the same vehicle. Recombinant α‐Klotho was sourced from R&D Systems (1819‐KL‐050; Minnesota, MN, USA). Animals were distributed into the following four experimental groups: sham‐operated

(3) Molecular Interaction of Soluble Klotho with FGF23 in the Pathobiology of Aortic Valve Lesions Induced by Chronic Kidney DiseaseInternational journal of biological sciencesJanuary 1, 2024The E, Zhai Y, Yao Q, Ao L, Fullerton DA, Meng X.

(4) Klotho increases antioxidant defenses in astrocytes and ubiquitin-proteasome activity in neuronsScientific reportsSeptember 12, 2023Orellana AM, Mazucanti CH, Dos Anjos LP, de Sá Lima L, Kawamoto EM, Scavone C.Sigma Chemicals (St. Louis, MO, U.S.A.), while recombinant α-Klotho was acquired from R&D Systems (1819-KL-050; Minnesota, MN, U.S.A). All solutions were freshly prepared prior to use. Animals and ethics All procedures

(5) Neuroprotective action of α-Klotho against LPS-activated glia conditioned medium in primary neuronal cultureScientific reportsNovember 7, 2022Nakao VW, Mazucanti CHY, de Sá Lima L, de Mello PS, de Souza Port's NM, Kinoshita PF, Leite JA, Kawamoto EM, Scavone C.purchased from Sigma Chemicals (St. Louis, MO, U.S.A.), and recombinant α-Klotho from R&D Systems (1819-KL-050, Minnesota, MN, U.S.A.). All solutions were prepared immediately before use. Primary cell culture Primary

(6) Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell deathThe Journal of biological chemistryNovember 1, 2022Shrestha S, Adib E, Imani J, Aguiar DJ, Lamattina AM, Tassew DD, Henske EP, Perrella MA, Priolo C, El-Chemaly S.

(7) Phosphate Metabolic Inhibition Contributes to Irradiation-Induced Myelosuppression through Dampening Hematopoietic Stem Cell SurvivalNutrientsAugust 18, 2022Wu Y, Liao W, Chen J, Liu C, Zhang S, Yu K, Wang X, Chen M, Wang S, Ran X, et al.

(8) Soluble α-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney diseaseKidney internationalAugust 1, 2022Yanucil C, Kentrup D, Campos I, Czaya B, Heitman K, Westbrook D, Osis G, Grabner A, Wende AR, Vallejo J, et al.recombinant protein produced by our lab is mouse (aa-35–982) and human (34–981). Mouse sKL from R&D Systems (1819KL050) is aa 35–982; human KL1 from Peprotech is aa 34–549. Heparin solution is for SPR experiments from Celsus

(9) Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenanceCell reportsFebruary 15, 2022Du C, Wang X, Wu Y, Liao W, Xiong J, Zhu Y, Liu C, Han W, Wang Y, Han S, et al.

(10) The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle functioneLifeApril 20, 2021Clemens Z, Sivakumar S, Pius A, Sahu A, Shinde S, Mamiya H, Luketich N, Cui J, Dixit P, Hoeck JD, et al.MSD) for 1 hr at room temperature. Dilutions of serum samples and murine recombinant Klotho standard (#1819 KL-050, R and D) were prepared in 1% blocker A solution and added to the MSD plate in a final volume of 25

(11) Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunctionMechanisms of ageing and developmentApril 1, 2021Zhuang X, Sun X, Zhou H, Zhang S, Zhong X, Xu X, Guo Y, Xiong Z, Liu M, Lin Y, et al.

(12) Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in miceMolecular metabolismFebruary 1, 2021Landry T, Li P, Shookster D, Jiang Z, Li H, Laing BT, Bunner W, Langton T, Tong Q, Huang H.

(13) Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infantsScientific reportsJuly 23, 2020Batlahally S, Franklin A, Damianos A, Huang J, Chen P, Sharma M, Duara J, Keerthy D, Zambrano R, Shehadeh LA, et al.

(14) Soluble Alpha-Klotho Alleviates Cardiac Fibrosis without Altering Cardiomyocytes RenewalInternational journal of molecular sciencesMarch 22, 2020Chen WY.of KL on the proliferation of H9c2 cells, the cells were cultured with KL (200 ng/mL, R&D Systems #1819-KL-050), FGF23 (100 ng/mL, R&D Systems 2629-FG-025), KL (200 ng/mL) plus FGF23 (100 ng/mL), KL (200 ng/mL)

(15) Klotho Alleviates Lung Injury Caused by Paraquat via Suppressing ROS/P38 MAPK-Regulated Inflammatory Responses and ApoptosisOxidative medicine and cellular longevityJanuary 1, 2020Zhang Z, Nian Q, Chen G, Cui S, Han Y, Zhang J.

(16) Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALSJournal of Molecular NeuroscienceOctober 1, 2019Ella Zeldich et al.rmKL that contains the shed ectodomain of Klotho (Ala35-Lys982, recombinant mouse Klotho, catalog no. 1819-KL-050 from R&D Systems, Minneapolis, MN) that was applied at a concentration of 0.4 μg/ml, 4 h before the

(17) Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysisJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and MetabolismAugust 1, 2019Mazucanti CH, Kawamoto EM, Mattson MP, Scavone C, Camandola S.

(18) Klotho deficiency affects the spine morphology and network synchronization of neuronsMolecular and cellular neurosciencesJuly 1, 2019Vo HT, Phillips ML, Herskowitz JH, King GD.to maintenance media at the first media change. When used, bioactive recombinant mouse KL (100ng/mL; 1819-KL-050; R&D Systems, Minneapolis, MN) (Leon et al. 2017; Vadakke Madathil et al. 2014; Lim et al. 2017; Laszczyk

(19) Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult HippocampusThe journals of gerontology. Series A, Biological sciences and medical sciencesJune 18, 2019Salech F, Varela-Nallar L, Arredondo SB, Bustamante DB, Andaur GA, Cisneros R, Ponce DP, Ayala P, Inestrosa NC, Valdés JL, et al.

(20) Administration of alpha klotho reduces liver and adipose lipid accumulation in obese miceHeliyonApril 1, 2019Rao Z, Landry T, Li P, Bunner W, Laing BT, Yuan Y, Huang H.

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7/12/2019Recombinant Mouse Klotho Protein is Bound by R&D MAB5334 Anonymous ReviewerThe reagent is suitable for ELISA.

Recombinant Mouse Klotho (aa 35-982) Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse Klotho (aa 35-982) Protein, CF from R&D Systems, a Bio-Techne Brand

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