Pyrophosphatase, inorganic (yeast) M2403L from New England Biolabs

Product Specs
ItemPyrophosphatase, inorganic (yeast)
CompanyNew England Biolabs
Price $298.00 Inquire
Catalog NumberM2403L
Size50 units
ApplicationsDNA Manipulation
TypeEnzymes
Temperature-20 C
Molecule NamePyrophosphatase, Inorganic

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New England Biolabs

240 County Road

Ipswich, Massachusetts 1938

United States

Phone: 800-632-5227
800-632-7799
978-921-1350

Company Profile

Website: http://www.neb.com

(1) Genomic diversity analysis enables development of pan-Dengue Toehold RNA sensorsPLoS Negl Trop DisApril 16, 2026Anirudh Nandakumar, Deeksha Mishra, Akshay Shendre, Edrea Mendonca, Soujanya Nagendra, Akash Gulyani, Arati Rameshenzyme (Toyobo, Cat. no. TRL-201), 2 μl (0.2 units) Yeast Inorganic Pyrophosphatase (NEB, Cat. no. M2403S), 0.5 μl (20 units) RNaseOUT (Invitrogen, Cat. no. 10777019), and the remainder of the reaction volume

(2) Protocol for formulation and evaluation of phytosterol-based lipid nanoparticles as cholesterol alternatives for mRNA deliverySTAR ProtocolsMarch 20, 2026Jaewook Lee, Jae Hoon Kim, Seung-Yeul Lee, Jun Hyeong Hong, Tae Jeong Oh, Sungwhan AnInhibitor,New England Biolabs,Cat#M0314S Inorganic Pyrophosphatase (yeast),New England Biolabs,Cat#M2403S T7 RNA Polymerase,New England Biolabs,Cat#M0251S CleanCap® Reagent M6,TriLink,Cat#N-7453 DNase I (RNase-free

(3) m6A-Modified Nucleotide Bases Improve Translation of In Vitro-Transcribed Chimeric Antigen Receptor (CAR) mRNA in T CellsInternational Journal of Molecular SciencesJanuary 13, 2026Nga Lao, Simeng Li, Marina Ainciburu, Niall BarronKit (Cat# RNT-102-L, Jena Biosciences, Thuringia, Germany) and yeast inorganic pyrophosphatase (Cat# M2403S, NEB, Ipswich, MA, USA) at a final concentration of 0.002U/ul. The resulting mRNAs were then treated

(4) Rapid expression of therapeutic antibodies in mammalian cells via mRNA transfectionMAbsDecember 12, 2025Thornwit Chavalparit, Craig Barry, Helen Gunter, Marianne Gillard, Timothy Mercer, Esteban Marcellindithiothreitol (DTT), 20 mM spermidine, 0.002% (v/v) Triton X-100), 2 U/mL yeast inorganic pyrophosphate (NEB, M2403), 1000 U/mL murine RNase inhibitor (NEB, M0314), Cap1 analogue, and 4 mM CleanCap AG reagents (TriLink,

(5) A novel plasmid-based co-tethered transcription platform for high yield, high purity mRNA synthesisNucleic Acids ResDecember 11, 2025Purnima Mala, Ruptanu Banerjee, Amin Abek, James Forster Iii, Aniruddha Pinjari, Ashish A Kulkarni, Craig T Martininhibitor (New England Biolabs, M0314S), 0.1 U yeast inorganic pyrophosphatase (New England Biolabs, M2403S), 7 mM ATP, 7 mM CTP, 7 mM GTP, 7 mM UTP, 4 mM CleanCap® reagent AG (Cap-1) (Trilink, N-7113-1) (enzymatic

(6) Cappable-Seq reveals the transcriptional landscape of stress responses in the bacterial endosymbiont WolbachiaMicrob GenomOctober 27, 2025Youseuf Suliman, Zhiru Li, Amit Sinha, Philip D. Dyer, Catherine S. Hartley, Laurence Ettwiller, Alistair C. Darby, Clotilde K. Carlow, Benjamin L. Makepeacevaccinia capping enzyme (NEB product number M2080), 5 µl inorganic pyrophosphate (NEB product number M2403) and ultrapure water (as needed) to a total volume of 50 µl and incubated at 37 °C for 1 h. Samples

(7) SELEX identifies high-affinity RNA targets for chromatin-binding proteins PARP1 and MeCP2iScienceAugust 6, 2025Manana Melikishvili, Kalpani De Silva, Darrell P. Chandler, Richard N. Cassidy, Kalina Andreeva, Hejer Dhahri, Eric C. Rouchka, Yvonne N. Fondufe-MittendorfRNaseOut Recombinant Ribonuclease Inhibitor,Invitrogen,Cat#10777019 DNAse I,Ambion,Cat#AM2222 "Pyrophosphate, Inorganic (yeast)",New England Biolabs,Cat#M2403L NuSieve GTG Agarose,Lonza Bioscience,Cat#50080 One Shot Top10 chemically competent E. coli,Invitrogen,Cat#4040-03 30K

(8) PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertilityNat CommunAugust 1, 2025Kehui Xiang, David P. BartelDTT25), 5 mM NTP Mix (Thermo Fisher, R0481), 0.2 U yeast inorganic pyrophosphatase (New England Biolabs, M2403L), 80 U SUPERase·In (Thermo Fisher, AM2694), 2 µg DNA template, and T7 RNA polymerase (purified in-house,

(9) Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapyNeuro-OncologyJuly 30, 2025Katie Lin, Christopher Zou, Akane Hubbard, Sasha Sengelmann, Laine Goudy, I-Ching Wang, Rohit Sharma, Joanna Pak, Kyla Foster, Tomoko Ozawa, et al.with the addition of RNAse Inhibitor (NEB, cat M0314L), and Yeast Inorganic Pyrophosphatase (NEB, cat M2403L). Transcribed mRNA was purified with Lithium Chloride and eluted in water. After quantification on a

(10) Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNANat CommunJuly 1, 2025Menglu Hu, Bingni Zhang, Yuanyue Shan, Feng Cao, Yihui Wang, Weiwei Qi, Xue Wang, Yuting Shen, Xinyi Guo, Mengmeng Zhang, et al.China, catalog number: M22101-5000), 4 U/mL Pyrophosphatase, Inorganic (yeast) (NEB, catalog number: M2403L), 400 nM FQT12, 200 nM F3/B3 primers, 1.6 µM FIP/BIP primers, 400 nM Loop F/B primers, 6 mM MgSO4 (NEB,

(11) Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell deathNat CommunJune 2, 2025Matthew B. Hanlon, Jason M. Shohet, Scot A. Wolferibonuclease inhibitor (40 U; Promega, #N2615), and yeast inorganic pyrophosphatase (New England Biolabs, #M2403S). Reaction mixture was incubated at 37 °C for 2 h before increasing the reaction volume to 50 µL with

(12) Optimized Preparation of Segmentally Labeled RNAs for NMR Structure DeterminationJournal of Molecular BiologyMay 15, 2025Brian D. Grossman, Bethel G. Beyene, Bersabel Tekle, William Sakowicz, Xinjie Ji, Joshua Miguele Camacho, Nandini Vaishnav, Amina Ahmed, Naman Bhandari, Kush Desai, et al.ng/μL DNA template, 0.13–0.17 μg/μL T7 RNAP, and 0.1 units of yeast inorganic pyrophosphatase (NEB M2403L). Reactions were incubated at 37 °C for 16–20 hours with agitation. Following incubation, RNA was purified

(13) Selective deuteration of an RNA:RNA complex for structural analysis using small-angle scatteringStructureApril 3, 2025Aldrex Munsayac, Wellington C. Leite, Jesse B. Hopkins, Ian Hall, Hugh M. O’Neill, Sarah C. KeaneRNaseOUT recombinant ribonuclease inhibitor,Invitrogen,Cat#10777019 Yeast inorganic pyrophosphatase,New England Biolabs,Cat#M2403S Dimethyl sulfoxide (DMSO),Fisher Scientific,Cat#BP231–100 Urea,Fisher Scientific,Cat#BP169–500 Ethylenediaminetetraacetic

(14) Chemical evolution of ASO-like DNAzymes for effective and extended gene silencing in cellsNucleic Acids ResMarch 4, 2025Yingyu Liu, Sheyu Zhang, Meiqi Zhang, Xin Liu, Yashu Wu, Qin Wu, John C Chaput, Yajun WangCat# B500056), 5 mM dithiothreitol (DTT), 2.5 U/ml of pyrophosphatase, inorganic (yeast) (NEB, Cat# M2403S), 1 U/μl of RNase Inhibitor (BBI, Cat# B600478) using 20 ng/μl of the purified DNA amplicon, and 5 U/μl

(15) Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteineJournal of Biological ChemistryMarch 4, 2025Genaro Hernandez, Adam Osinski, Abir Majumdar, Jennifer L. Eitson, Monika Antczak, Krzysztof Pawłowski, Hanspeter Niederstrasser, Kelly A. Servage, Bruce Posner, John W. Schoggins, et al.(M0492L), all restriction enzymes used for cloning, proteinase K (P8107S), yeast inorganic pyrophosphatase (M2403) were obtained from New England Biolabs. ATP (R0441), acetic acid (A38-212), 2× TBE-urea sample buffer

(16) MCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assaysThe EMBO journalFebruary 1, 2025Meurs R, De Matos M, Bothe A, Guex N, Weber T, Teleman AA, Ban N, Gatfield D.the CleanCap Reagent AG (3′ Ome) (N-7413, TriLink) and the Yeast Inorganic Pyrophosphatase (Cat. No. M2403S, New England BioLabs) following the CleanCap protocol. The capped RNAs were treated for 15 min at 37

(17) RAG-seq: NSR-primed and Transposase Tagmentation-mediated Strand-specific Total RNA Sequencing in Single CellsGenomics, Proteomics & BioinformaticsDecember 3, 2024Ping Xu, Zhiheng Yuan, Xiaohua Lu, Peng Zhou, Ding Qiu, Zhenghao Qiao, Zhongcheng Zhou, Li Guan, Yongkang Jia, Xuan He, et al.NTP (Catalog No. B600056, Sangon Biotech), 0.5 μl RNase inhibitor, 0.5 μl 0.1 U/μl YIPP (Catalog No. M2403, New England Biolabs), and 1 μl 50 U/μl T7 RNA polymerase (Catalog No. EG201225S, YuGong Biotech, Lianyungang,

(18) Base Editing of Human Hematopoietic Stem CellsMethods in Molecular BiologySeptember 20, 2024Jing Zeng, Gabriele Casirati, My Anh Nguyen, Pietro Genovese, Daniel E. BauerHiScribe high yield in vitro transcription kit (NEB, #E2040S), Yeast inorganic pyrophosphatase (NEB, #M2403L), murine RNAse inhibitor (NEB, #314L), NEB Monarch RNA Cleanup Columns, 500 ug, (cat.no. T2057L, Agilent

(19) Plug-and-play protein biosensors using aptamer-regulated in vitro transcriptionNature communicationsSeptember 12, 2024Lee H, Xie T, Kang B, Yu X, Schaffter SW, Schulman R.µl−1, EP0113). NEB RNAPol reaction buffer (M0251S; 10X) and yeast inorganic pyrophosphatase (YIPP; M2403S; 0.1 U µl−1) were purchased from New England Biolabs (NEB). RNase H was purchased from ThermoFisher Scientific

(20) Improving prime editing with an endogenous small RNA-binding proteinNatureApril 18, 2024Jun Yan, Paul Oyler-Castrillo, Purnima Ravisankar, Carl C. Ward, Sébastien Levesque, Yangwode Jing, Danny Simpson, Anqi Zhao, Hui Li, Weihao Yan, et al.RNase inhibitor (New England Biolabs, M0314L) and yeast inorganic pyrophosphatase (New England Biolabs, M2403L) for T cell experiments. All mRNA was produced with UTP fully replaced with N1-methylpseudouridine-5′-triphosphate

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Pyrophosphatase, inorganic (yeast)

Pyrophosphatase, inorganic (yeast) from New England Biolabs

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New England Biolabs

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Pyrophosphatase, inorganic (yeast) from New England Biolabs

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