KU-55933, competitive ATM kinase inhibitor ab120637 from Abcam

Product Specs
ItemKU-55933, competitive ATM kinase inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120637
Size10 mg
Purity0.99
TypeInhibitor, inhibitor
Molecule Name2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one

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United Kingdom

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+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Hepatitis C Virus Core Induces p53 Ser-15 Phosphorylation to Facilitate E6-Associated Protein-Mediated Proteasomal Degradation of p53CellsFebruary 27, 2026Hyunyoung Yoon, Ji-Min Park, Jiwoo Han, Yerin Kwon, Kyung Lib JangUSA), and 100 units/mL penicillin G (Sigma-Aldrich #P3032). Cells were treated with KU-55933 (Abcam #ab120637, Cambridge, UK), MG132 (Millipore #474790; Burlington, MA, USA), CHX (Sigma-Aldrich #C7698), etoposide

(2) USP25 Elevates SHLD2-Mediated DNA Double-Strand Break Repair and Regulates Chemoresponse in CancerAdvanced science (Weinheim, Baden-Wurttemberg, Germany)July 1, 2024Li Y, Li L, Wang X, Zhao F, Yang Y, Zhou Y, Zhang J, Wang L, Jiang Z, Zhang Y, et al.F6627‐1G; Sigma‐Aldrich), cisplatin (S1166, Selleck), cycloheximide (CHX: HY12320, Sigma‐Aldrich), Ku55933 (ab120637, Abcam), λ‐phosphatase (P0753S, New England BioLabs), MG132 (C2211, Sigma‐Aldrich), IPTG (isopropyl‐β‐d‐thiogalactopyranoside,

(3) The DNA damage-independent ATM signalling maintains CBP/DOT1L axis in MLL rearranged acute myeloid leukaemiaOncogeneJune 14, 2024Guangming Wang, Wenjun Zhang, Jie Ren, Yu Zeng, Xiuyong Dang, Xiaoxue Tian, Wenlei Yu, Zheng Li, Yuting Ma, Pingping Yang, et al.MedChemExpress, #HY-12320), MG132 (Selleck, #2619), Chloroquine (CHQ, Selleck, #6999), KU-55933 (Abcam, #ab120637), Etoposide (ETO, MedChemExpress, # HY-13629), Hydroxyurea (HU, Sigma-Aldrich, #H8627). Synthesised

(4) Rapid phosphorylation of glucose-6-phosphate dehydrogenase by casein kinase 2 sustains redox homeostasis under ionizing radiationRedox BiologySeptember 1, 2023Yilong Hao, Tao Ren, Xiaoke Huang, Mi Li, Jong-Ho Lee, Qianming Chen, Rui Liu, Qingfeng TangAntibodies recognizing GST (#2624), and CK2α (#2656) were purchased from Cell Signaling Technology. KU55933 (ab120637), and antibodies recognizing Tubulin (ab7291), Flag (ab205606), and G6PD (ab231828) were purchased from

(5) A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumorsSignal transduction and targeted therapyMay 10, 2023Zhang C, Guo Q, Chen L, Wu Z, Yan XJ, Zou C, Zhang Q, Tan J, Fang T, Rao Q, et al.O-9201), 10 µM DNA-PK inhibitor AZD7648 (ChemScene, CS-0091859), 10 µM ATM inhibitor KU55933 (Abcam, ab120637) or 10 µM ATR inhibitor VX970 (Selleckchem, S7102) for 6 h. After washing with PBS, cells were fixed

(6) BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβOpen biologyOctober 1, 2021Bunch H, Jeong J, Kang K, Jo DS, Cong ATQ, Kim D, Kim D, Cho DH, Lee YM, Chen BPC, et al.serum media for 17.5 h. The media were exchanged with the 0.1% serum media including KU55933 (Abcam, ab120637), VE821 (Sigma, SML-1415) or caffeine (Sigma, C0750) at a final concentration of 10 µM, 1 µM or 3 mM

(7) Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin actionCell reportsJuly 13, 2021Isobe SY, Hiraga SI, Nagao K, Sasanuma H, Donaldson AD, Obuse C.Mirin,Abcam,Cat# ab141182 PARP inhibitor Olaparib,Selleckchem,Cat# S1060 ATM inhibitor KU55933,Abcam,Cat# ab120637 Neocarzinostatin,Sigma-Aldrich,Cat# N9162 Lipofectamine RNAiMAX,Thermo Fisher,Cat# 133778-150 Lipofectamine

(8) Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in miceScientific ReportsDecember 1, 2020Masahiro Uehara et al.4, or 14 days after the last cisplatin injection. For ATM inhibition in vivo, 5 mg/kg of KU-55933 (ab120637, Abcam plc., Cambridge, UK) or vehicle (10% DMSO in saline) was intraperitoneally administered 30 minutes

(9) Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunctionThe EMBO journalNovember 2, 2020Sun C, Wang K, Stock AJ, Gong Y, Demarest TG, Yang B, Giri N, Harrington L, Alter BP, Savage SA, et al.Olaparib (S1060, Selleckchem), SIRT1 inhibitor, EX 527 (S1541, Selleckchem), or ATM inhibitor KU‐55933 (ab120637, Abcam) in Gibco Dulbecco's modified Eagle's medium supplemented with 15% fetal bovine serum, penicillin‐streptomycin,

(10) Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against AgingMolecular cellSeptember 3, 2020Huang J, Zhou Q, Gao M, Nowsheen S, Zhao F, Kim W, Zhu Q, Kojima Y, Yin P, Zhang Y, et al.8.18708 Camptothecin,Sigma-Aldrich,Cat# C9911 Cisplatin,Sigma-Aldrich,Cat# P4394 ATM kinase inhibitor KU55933,Abcam,Cat# ab120637 ATR kinase inhibitor VX970,"National Cancer Institute (Rockville, MD)",N/A ATPase VCP/p97 Inhibitor

(11) The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylationeLifeAugust 24, 2020Okumoto K, El Shermely M, Natsui M, Kosako H, Natsuyama R, Marutani T, Fujiki Y.,Cell signaling,9903S, "Chemical compound, drug",SB203580,Cell signaling,5633S, "Chemical compound, drug",KU-55933,Abcam,ab120637, "Chemical compound, drug",Compound C,Merck,171260, "Chemical compound, drug",Complete protease inhibitor

(12) TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrityNucleic acids researchAugust 22, 2019Meng Y, Liu C, Shen L, Zhou M, Liu W, Kowolik C, Campbell JL, Zheng L, Shen B.concentration of 100 μM. The ataxia-telangiectasia mutated (ATM) inhibitor KU-55933 (Abcam, Catalog #ab120637) was added for 12 h at a final concentration of 10 μM. Protein expression and purification Recombinant protein expression

(13) The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanismsGenes & DevelopmentMarch 1, 2019Alexander J. Garvin et al.aphidocolin, 2 mM thymidine, 150 ng/mL nocodazole (Sigma), 10 µM EdU (Life Technologies), and KU55933 (Abcam, ab120637). NHEJ and HR assays U2OS-DR3-GFP (gene conversion), and U2OS-EJ5-GFP (NHEJ) were a generous gift

(14) Feedback regulation of methyl methanesulfonate and ultraviolet-sensitive gene clone 81 via ATM/Chk2 pathway contributes to the resistance of MCF-7 breast cancer cells to cisplatinTumor BiologyMarch 29, 2017Juan Lv, Ying Qian, Xiaoyan Ni, Xiuping Xu, Xuejun Dongat 37°C in 5% CO2. Cisplatin was purchased from Sigma (St. Louis, MO, USA). ATM inhibitor (KU55933, ab120637) and Chk2 inhibitor (AZD7762, S1532) were provided by Abcam (Cambridge, UK) and Selleck (Houston, TX,

(15) Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemiaNeuroscienceFebruary 17, 2017Taichiro Imahori, Kohkichi Hosoda, Tomoaki Nakai, Yusuke Yamamoto, Yasuhiro Irino, Masakazu Shinohara, Naoko Sato, Takashi Sasayama, Kazuhiro Tanaka, Hiroaki Nagashima, Masaaki Kohta, Eiji Kohmura

(16) Transcriptional elongation requires DNA break-induced signallingNature communicationsDecember 16, 2015Bunch H, Lawney BP, Lin YF, Asaithamby A, Murshid A, Wang YE, Chen BP, Calderwood SK.in this study are as follows: NU7441 from Tocris Bioscience (Cat. No 3712) and KU55933 from Abcam (ab120637). Stock solutions (1,000 × ) were made dissolving the inhibitors as 2 mM and 10 mM in DMSO to target

(17) Cyclo(phenylalanine-proline) induces DNA damage in mammalian cells via reactive oxygen speciesJournal of cellular and molecular medicineDecember 1, 2015Lee K, Jeong JE, Kim IH, Kim KS, Ju BG.Bachem, Bubendorf, Switzerland) were dissolved in DMEM containing 10% FBS and antibiotics. KU‐55933 (ab120637; Abcam, Cambridge, MA, USA) was dissolved in DMSO. Doxorubicin (D1317; Sigma‐Aldrich) and N‐acetylcysteine

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KU-55933, competitive ATM kinase inhibitor from Abcam

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KU-55933, competitive ATM kinase inhibitor from Abcam

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