Description
An isoprostane; induces calcium influx in HEK293 cells expressing human TRPA1 and isolated mouse trigeminal neurons at 100 µM; potentiates glutamate-induced cytotoxicity and decreases GSH levels in HT22 hippocampal cells at 1 and 30 µM, respectively; inhibits VEGF-induced migration and tube formation of human coronary artery endothelial cells at 10 µM, an effect that can be reversed by SQ 29,548