Recombinant Human Notch-1 Fc Chimera Protein, CF 3647-TK-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Notch-1 Fc Chimera Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $449.00Supplier Page View Company Product Page
Catalog Number3647-TK-050
FormatLyophilized from a 0.2 µm filtered solution in PBS
SpeciesHuman
Size50 ug
Molecule NameNotch-1
NCBI Full Gene Namenotch receptor 1
NCBI Gene AliaseshN1, AOVD1, AOS5, TAN1
Purity>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 115-125 kDa, reducing conditions
Theoretical: 80.1 kDa (monomer)
ApplicationsBinding Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human Notch-1 Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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(2) ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical ModelsMolecular cancer therapeuticsMay 1, 2018Li Y, Hickson JA, Ambrosi DJ, Haasch DL, Foster-Duke KD, Eaton LJ, DiGiammarino EL, Panchal SC, Jiang F, Mudd SR, et al.

(3) Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1The Journal of biological chemistryAugust 30, 2013Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC.

(4) Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusionBloodJune 1, 2007Scehnet JS, Jiang W, Kumar SR, Krasnoperov V, Trindade A, Benedito R, Djokovic D, Borges C, Ley EJ, Duarte A, et al.

Recombinant Human Notch-1 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand