Native Clostridium difficile Toxin B protein ab124001 from Abcam

Product Specs
ItemNative Clostridium difficile Toxin B protein
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab124001
FormatClostridium difficile Toxin B has been highly purified
Size50 µg
ApplicationsFuncS, SDS-PAGE
Gene NametcdB
Source/Expression SystemNative
ActivityActive
Research AreaImmunology & Infectious Disease
TypeProteins
Molecule NametcdB

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) The Black Soldier Fly Hermetia illucens Larva Presents an Antimicrobial Activity in Response to Clostridioides difficile ExposureCurrent Research in Microbial SciencesDecember 30, 2025Aviel Melchior, Maya Azrad, Boris Fichtman, Avi PeretzBHIS into BSFL (Control 1) or BSFL without any treatment (Control 2). Native toxin A (ab123999) and B (ab124001) (Abcam, Cambridge, UK) were diluted in double distilled water to a final concentration of 200 ng/ml,

(2) CD44 is a macrophage receptor for TcdB from Clostridioides difficile that via its lysine-158 succinylation contributes to inflammationGut microbesDecember 1, 2025Chen Z, Zhang W, Wang D, Luo R, Yao Y, Tao X, Li L, Pan Q, Sun X.10852-H02H; SinoBiological, China) were used in an ELISA. Native TcdB was obtained from Abcam (Cat# ab124001). Various receptor proteins were separately immobilized onto ELISA plates, followed by sequential addition

(3) Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infectionCell ReportsApril 22, 2025Kevin S. Mears, Joshua E. Denny, Jeffrey R. Maslanka, Nontokozo V. Mdluli, Ellie N. Hulit, Rina Matsuda, Emma E. Furth, Charlie G. Buffie, Michael C. AbtIL-23,Biolegend,589004 Foxp3/Transcription Factor staining buffer set,eBioscience,00-5523-00 C. difficile Toxin B (TcdB),Abcam,ab124001 RNAlater,Invitrogen,AM7024 QuantiTect Reverse Transcription kit,Qiagen,205314 DyNamo ColorFlash Probe qPCR kit

(4) Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variantsNature ImmunologyFebruary 10, 2025Shouya Feng, Matthew C. Wierzbowski, Katja Hrovat-Schaale, Andreas Dumortier, Yaoyuan Zhang, Maria Zyulina, Paul J. Baker, Thomas Reygaerts, Annemarie Steiner, Dominic De Nardo, et al.IFN-γ (1 μg ml−1, R&D systems, 285-IF-100) for 24 h and then treated with TcdB (200 ng ml−1, Abcam, ab124001) for 14 h. To induce THP-1 differentiation, cells were treated with 100 ng ml−1 phorbol-12-myristat-13-acetat

(5) Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanismCell ReportsOctober 11, 2022Flora Magnotti, Daria Chirita, Sarah Dalmon, Amandine Martin, Pauline Bronnec, Jeremy Sousa, Olivier Helynck, Wonyong Lee, Daniel L. Kastner, Jae Jin Chae, et al.Chemicals. LPS-EB Ultrapure (#tlrl-3pelps), Nigericin (#tlrl-nig) were from Invivogen. TcdB was from Abcam (#ab124001). TcdA was purified from Clostridium difficile VPI10463 strain, as previously described (von Eichel-Streiber

(6) ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activationThe Journal of experimental medicineSeptember 6, 2021Li S, Wang L, Xu Z, Huang Y, Xue R, Yue T, Xu L, Gong F, Bai S, Wu Q, et al.with 50 ng ml−1 LPS (Sigma-Aldrich, L4391) for 4 h and then stimulated with 500 ng ml−1 TcdB (Abcam, ab124001) for 1 h. Statistical analysis Statistical analyses were performed with Mann–Whitney U test, unpaired

(7) Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patientsEMBO molecular medicineNovember 7, 2019Magnotti F, Lefeuvre L, Benezech S, Malsot T, Waeckel L, Martin A, Kerever S, Chirita D, Desjonqueres M, Duquesne A, et al.#4034771, #4027402, respectively), VX‐765 (InvivoGen), 30 min before addition of UCN‐01, TcdB (Abcam, #ab124001, 125 ng/ml), and TcdA (1 μg/ml) or nigericin. TcdA was purified from Clostridioides difficile VPI10463

(8) Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficileInfection and ImmunityMarch 1, 2019Lauren E. Hartley-Tassell, Milena M. Awad, Kate L. Seib, Maria Scarselli, Silvana Savino, Joe Tiralongo, Dena Lyras, Christopher J. Day, Michael P. Jenningswere expressed and puriﬁed as previously described (22). Full-length TcdB was purchased from Abcam (ab124001). Glycan array. Glycans were prepared for printing as described by Day et al. (34). Glycan array slides were

(9) A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean FeverAnnals of the rheumatic diseasesDecember 1, 2017Moghaddas F, Llamas R, De Nardo D, Martinez-Banaclocha H, Martinez-Garcia JJ, Mesa-Del-Castillo P, Baker PJ, Gargallo V, Mensa-Vilaro A, Canna S, et al.Where indicated, cells were treated with Clostridium difficile Toxin B protein (TcdB, 5µg/ml, Abcam ab124001) 16h before harvesting. Cell lysates were generated 48h after transfection using 1% NP-40 lysis buffer

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Native Clostridium difficile Toxin B protein from Abcam

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Native Clostridium difficile Toxin B protein from Abcam

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