Description
An inhibitor of sphingolipid biosynthesis; inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates at 5 and 10 µM; reduces the synthesis of glucosylceramide increases cellular ceramide, and induces cell cycle arrest; increases Aβ42 and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity