Description
An oxidosqualene cyclase inhibitor with cholesterol lowering activity; inhibits OSC from human liver microsomes and HepG2 cells (IC50s = ~6.5 and ~1.5 nM, respectively); lowered LDL cholesterol ~40% in hamsters without affecting HDL levels and no sign of liver toxicity at 150 µg/kg; increases cytochrome P3A mRNA and protein levels in primary rat and murine hepatocyte cultures at 30 µM