5α-hydroxy-6-keto Cholesterol from Cayman Chemical

An active metabolite of cholesterol-5,6-epoxides; inhibits cholesterol synthesis in 16HBE cells (IC50 = 350 nM); increases the proliferation of MDA-MB-231 and MDA-MB-468 cells at 2 and 5 µM; increases tumor volume in MCF-7, MDA-MB-231, EO771, and MDA-MB-468 breast cancer mouse xenograft models at 50 µg/kg