SignalSilence ® Ezh2 siRNA I 6509S from Cell Signaling Technology

Product Specs
ItemSignalSilence ® Ezh2 siRNA I
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6509S
NCBI Gene AliasesENX-1, ENX1, EZH2b, KMT6, KMT6A, WVS, WVS2
NCBI Full Gene Nameenhancer of zeste 2 polycomb repressive complex 2 subunit
TargetEZH2
Research AreaChromatin Regulation / Nuclear Function
ReactivityH
ApplicationssiRNA
TypesiRNA
Size300 µl

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Combinational Inhibition of the eIF4F Complex, AKT1, and EZH2 Enhances Anticancer Effects in BRAF^V600E Mutant A375 Melanoma CellsOncology ResearchFebruary 24, 2026Yuanxin Miao, Fengyun Hao, Sae Hwi KisiRNA(sc-29226), c-Jun siRNA (sc-29223), c-Fos siRNA (sc-44200), and EGR1 siRNA (sc-44203). EZH2 siRNA (#6509) was purchased from Cell Signaling Technology (CST, Danvers, MA, USA). All negative control siRNAs were

(2) Downregulation of EZH2 Promotes Renal Epithelial Cellular Senescence and Kidney AgingThe FASEB JournalMay 15, 2025Yingying Zhang, Chen Yu, Ewud Agborbesong, Xiaogang Li(siRNA) and EZH2 plasmid transfection The RNA oligonucleotides that specifically targeted human EZH2 (#6509) and human p53 (#6231) were purchased from Cell signaling Technology Inc. The RNA oligonucleotides were

(3) Downregulation of EZH2 promotes renal epithelial cellular senescence and kidney agingFASEB JMay 15, 2025Yingying Zhang, Chen Yu, Ewud Agborbesong, Xiaogang Li(siRNA) and EZH2 plasmid transfection The RNA oligonucleotides that specifically targeted human EZH2 (#6509) and human p53 (#6231) were purchased from Cell signaling Technology Inc. The RNA oligonucleotides were

(4) S-nitrosylation of EZH2 alters PRC2 assembly, methyltransferase activity, and EZH2 stability to maintain endothelial homeostasisNat CommunApril 27, 2025Ashima Sakhuja, Ritobrata Bhattacharyya, Yash Tushar Katakia, Shyam Kumar Ramakrishnan, Srinjoy Chakraborty, Hariharan Jayakumar, Shailesh Mani Tripathi, Niyati Pandya Thakkar, Sumukh Thakar, Sandeep Sundriyal, et al.for immunoblotting and immunofluorescence experiments. EZH2 small-interfering RNA (SignalSilence® Ezh2 siRNA I #6509) and control siRNA (SignalSilence® Control siRNA#6568) were obtained from Cell Signaling Technology.

(5) Identification of Poliovirus Receptor-like 3 Protein as a Prognostic Factor in Triple-Negative Breast CancerCellsAugust 3, 2024Gian Marco Leone, Katia Mangano, Salvatore Caponnetto, Paolo Fagone, Ferdinando Nicolettivector was prepared via transfecting 3 × 106 of each cell line with 100 nM of validated siRNA for EZH2 (6509, Cell Signaling Technology, Danvers, MA, USA) or a negative control (6568, Cell Signaling Technology),

(6) Intermittent High Glucose Elevates Nuclear Localization of EZH2 to Cause H3K27me3-Dependent Repression of KLF2 Leading to Endothelial InflammationCellsSeptember 26, 2021Thakar S, Katakia YT, Ramakrishnan SK, Pandya Thakkar N, Majumder S.Endothelial Cells Prevalidated human-specific EZH2 small-interfering RNA (SignalSilence® Ezh2 siRNA I #6509) and control siRNA (SignalSilence® Control siRNA#6568) were from Cell Signaling Technology. EZH2 siRNA

(7) An E2F1/DDX11/EZH2 Positive Feedback Loop Promotes Cell Proliferation in Hepatocellular CarcinomaFrontiers in oncologyJanuary 1, 2020Su SG, Li QL, Zhang MF, Zhang PW, Shen H, Zhang CZ.Santa-cruz Biotechnology), E2F2 (sc-29298, Santa-cruz Biotechnology), E2F3 (sc-37817, Santa-cruz Biotechnology), and EZH2 (#6509, Cell Signaling Technology) were also transiently introduced into HCC cells. Quantitative Real-Time Polymerase Chain Reaction

(8) EZH2 inhibitors-mediated epigenetic reactivation of FOSB inhibits triple-negative breast cancer progressCancer cell internationalJanuary 1, 2020Zhang R, Li X, Liu Z, Wang Y, Zhang H, Xu H.WI). Control-siRNAs were from Santa Cruz (sc-37007). EZH2-siRNAs were from Cell Signaling Technology (6509), CEBPB-siRNAs were from Santa Cruz (sc-29229) and SUZ12-siRNA (h) were from Santa Cruz (sc-45597). Western blotting

(9) EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathwayOncogeneJanuary 1, 2020Zhang H, Zhu D, Zhang Z, Kaluz S, Yu B, Devi NS, Olson JJ, Van Meir EG.TransIT-X2 transfection reagent (Mirus, Madison, WI). EZH2-siRNAs were from Cell Signaling Technology (6509) and OriGene (SR320099). Control-siRNAs were from Santa Cruz (sc-37007) and OriGene (SR30004). EP300-siRNAs

(10) Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver FibrosisCellular and molecular gastroenterology and hepatologyJanuary 1, 2019Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, et al.overnight starvation, human HSCs were transfected with 100 nmol/L of siRNA (SignalSilence Ezh2 siRNA I 6509; Cell Signaling Technology) using Oligofectamine (12252011; Invitrogen) according to the manufacturer’s

(11) Dissection of Myogenic Differentiation Signatures in Chickens by RNA-Seq AnalysisGenesJanuary 11, 2018Li T, Zhang G, Wu P, Duan L, Li G, Liu Q, Wang J.

(12) Simulation of therapeutic electron beam tracking through a non-uniform magnetic field using finite element methodElectronic physicianApril 25, 2017Mohammad Javad Tahmasebibirgani, Reza Maskani, Mohammad Ali Behrooz, Mansour Zabihzadeh, Hojatollah Shahbazian, Jafar Fatahiasl, Nahid Chegeniand transverse linac-MRIs using Monte Carlo and realistic 3D MRI field models. Med phys. 2012; 39(10): 6509-21. doi: 10.1118/1.4754657. PMID: 23039685. 20) Kirkby C, Stanescu T, Rathee S, Carlone M, Murray B

(13) BAR-SH3 sorting nexins are conserved interacting proteins of Nervous wreck that organize synapses and promote neurotransmissionJournal of cell scienceJanuary 1, 2016Ukken FP, Bruckner JJ, Weir KL, Hope SJ, Sison SL, Birschbach RM, Hicks L, Taylor KL, Dent EW, Gonsalvez GB, et al.Cell Signaling Technologies, Danvers, MA), chicken polyclonal anti-NWK2 (western blotting, 1:1000; #6509, ProSci, Poway, CA), rabbit polyclonal anti-Nwk (immunofluorescence, 1:1000) (Coyle et al., 2004), rabbit

(14) Inhibition enhancer of zeste homologue 2 promotes senescence and apoptosis induced by doxorubicin inp53mutant gastric cancer cellsCell ProliferationJune 1, 2014J. Bai, M. Ma, M. Cai, F. Xu, J. Chen, G. Wang, X. Shuai, K. TaoNM_004456.4) and negative control siRNA were purchased from Cell Signaling Technology (Boston, MA, USA) (6509S, 6201S). Fifty to sixty per cent conﬂuent gastric cancer cells were transfected ith 100 nM of siRNA

(15) Thiol Redox Transitions in Cell Signaling: a Lesson from N-AcetylcysteineThe Scientific World JOURNALJune 29, 2010Tiziana Parasassi, Roberto Brunelli, Graziella Costa, Marco De Spirito, Ewa Krasnowska, Thomas Lundeberg, Eugenia Pittaluga, Fulvio UrsiniElectrostatic influence of local cysteine environments on disulfide exchange kinetics. Biochemistry 20, 6509–6519. 1200 Parasassi et al.: Thiol Redox Transitions in Cell Signaling 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. TheScientificWorldJOURNAL

(16) A Myelin Galactolipid, Sulfatide, Is Essential for Maintenance of Ion Channels on Myelinated Axon But Not Essential for Initial Cluster FormationThe Journal of NeuroscienceAugust 1, 2002Tomoko Ishibashi, Jeffrey L. Dupree, Kazuhiro Ikenaka, Yukie Hirahara, Koichi Honke, Elior Peles, Brian Popko, Kinuko Suzuki, Hitoo Nishino, Hiroko BabaPNS were affected to a similar extent as those in the J. Neurosci., August 1, 2002, 22(15):6507–6514 6509 Figure 2. CST-deficient mice revealed severely disrupted Caspr clustering both in the CNS and in the

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SignalSilence ® Ezh2 siRNA I

SignalSilence ® Ezh2 siRNA I from Cell Signaling Technology

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SignalSilence ® Ezh2 siRNA I from Cell Signaling Technology

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