Recombinant Human Nodal Protein, CF 3218-ND-025/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Nodal Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $563.00Supplier Page View Company Product Page
Catalog Number3218-ND-025/CF
Molecule NameNodal
NCBI Full Gene Namenodal growth differentiation factor
NCBI Gene AliasesHTX5
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight12.9 kDa (monomer)
Conjugate/TagUnconjugated
ApplicationsBioactivity
Source/Expression SystemE. coli-derived Recombinant Human Nodal Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
Size25 ug
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA

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(1) A vector-encoded bispecific killer engager to harness virus-activated NK cells as anti-tumor effectorsCell death & diseaseFebruary 10, 2023Floerchinger A, Klein JE, Finkbeiner MSC, Schäfer TE, Fuchs G, Doerner J, Zirngibl H, Ackermann M, Kvasnicka HM, Chester KA, et al.

(2) TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoidsStem cell reportsOctober 11, 2022Watanabe M, Buth JE, Haney JR, Vishlaghi N, Turcios F, Elahi LS, Gu W, Pearson CA, Kurdian A, Baliaouri NV, et al.

(3) Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell MigrationCancersAugust 20, 2022Pérez-García J, Martel-Martel A, García-Vallés P, Corchete LA, García JL, Gestoso-Uzal N, Vidal-Tocino R, Blanco Ó, Méndez L, Sánchez-Martín M, et al.

(4) Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumoursBMC cancerApril 23, 2020Harpelunde Poulsen K, Nielsen JE, Grønkær Toft B, Joensen UN, Rasmussen LJ, Blomberg Jensen M, Mitchell RT, Juul A, Rajpert-De Meyts E, Jørgensen A.

(5) In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common MarmosetsScientific reportsFebruary 26, 2020Vermilyea SC, Babinski A, Tran N, To S, Guthrie S, Kluss JH, Schmidt JK, Wiepz GJ, Meyer MG, Murphy ME, et al.

(6) Intrinsic cellular chirality regulates left-right symmetry breaking during cardiac loopingProceedings of the National Academy of Sciences of the United States of AmericaDecember 11, 2018Ray P, Chin AS, Worley KE, Fan J, Kaur G, Wu M, Wan LQ.

(7) Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal TestisCell reportsNovember 13, 2018Jørgensen A, Macdonald J, Nielsen JE, Kilcoyne KR, Perlman S, Lundvall L, Langhoff Thuesen L, Juul Hare K, Frederiksen H, Andersson AM, et al.

(8) ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell lineOncology lettersDecember 1, 2017Jiang Y, Li H, Wang Y, Tian T, He Y, Jin Y, Han C, Jin X, Zhang F, Morii E.

(9) Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenograftsEMBO molecular medicineJuly 1, 2017Ball CR, Oppel F, Ehrenberg KR, Dubash TD, Dieter SM, Hoffmann CM, Abel U, Herbst F, Koch M, Werner J, et al.

(10) A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTOThe Journal of cell biologyDecember 5, 2016Lee GH, Fujita M, Takaoka K, Murakami Y, Fujihara Y, Kanzawa N, Murakami KI, Kajikawa E, Takada Y, Saito K, et al.

(13) Designer nodal/BMP2 chimeras mimic nodal signaling, promote chondrogenesis, and reveal a BMP2-like structureThe Journal of biological chemistryJanuary 17, 2014Esquivies L, Blackler A, Peran M, Rodriguez-Esteban C, Izpisua Belmonte JC, Booker E, Gray PC, Ahn C, Kwiatkowski W, Choe S.

(14) Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitorsNatureJuly 26, 2012Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, et al.

(15) Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growthThe Journal of biological chemistryAugust 26, 2011Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, et al.

(17) Requirement of glycosylphosphatidylinositol anchor of Cripto-1 for trans activity as a Nodal co-receptorThe Journal of biological chemistryDecember 7, 2007Watanabe K, Hamada S, Bianco C, Mancino M, Nagaoka T, Gonzales M, Bailly V, Strizzi L, Salomon DS.

(18) Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressedStem CellsJanuary 1, 2007McLean AB, D'Amour KA, Jones KL, Krishnamoorthy M, Kulik MJ, Reynolds DM, Sheppard AM, Liu H, Xu Y, Baetge EE, et al.

Recombinant Human Nodal Protein, CF from R&D Systems, a Bio-Techne Brand