Description
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Over 1000 serpins have been identified including 36 human proteins. As a member of the Serpin superfamily and the primary physiological inhibitor of the serine protease plasmin, Serpin F2 is responsible for the dissolution of fibrin clots. Serpin F2 is mainly expressed by liver and kidney, while other tissues such as muscle, intestine, central nervous system, and placenta also express this protein at a moderate level