Description
E-selectin, also known as CD62E is an inducible leukocyte adhesion glycoprotein specifically expressed by endothelial cells. E-selectin helps initiate recruitment of circulating leukocytes to cutaneous, bone and inflamed tissues. E-selectin is found in inflammatory skin lesions in psoriasis, contact dermatitis, and delayed- type hypersensitivity, in arthritic joints, and in heart and renal allografts undergoing rejection. E-selectin-targeting antibody drug conjugate has potential as a prostate cancer therapy