Description
Fms-Like tyrosine kinase 3 (FLT3) is a member of the class III tyrosine kinase receptor family, normally expressed in hematopoietic, immune and neural systems. FLT3 is expressed in various lymphohematopoietic cells and tissues, including a series of immature cell lines and leukemias of lymphocytic origin. FLT3 is a promising target for the therapeutic intervention for acute leukemias, particularly acute myeloid leukemia (AML) which are severe and aggressive malignancy