Description
SENP1 fragment has been reported to co-localize with a herpes virus protein ICP0 during early infection. This co-localization may be involved in the ICP0-induced loss of SUMO-1-modified PML in infected cells. Characterization of the localization and regulation of SENP1 has also been reported. SENP1 localization may also be influenced by the expression of proteins that are targets of SUMO-1 modification, such as HDAC4 and PML, which affect the relative levels and localization of SUMO-1 conjugates within the cell